Cerebral Small Vessel Diseases Clinical Trial
Official title:
Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel Disease
The present study aims at verifying the mutual effects between intracranial large artery atherosclerosis and cerebral small vessel disease on disease progression and prognosis by magnetic resonance imaging, and providing biomarkers for the early prevention and treatment of cerebrovascular disease.
Cerebrovascular disease is the most common cause of death worldwide. There is a close link in structure and function between the intracranial large arteries and cerebral small vessels. Moreover, growing evidences have demonstrated that large artery atherosclerosis often coexists with small vessel disease, which may deteriorate the clinical outcomes of stroke and dementia. The mutual feedback mechanism between them is not fully understood. The present study focuses on the mechanism of mutual feedback between large artery atherosclerosis and cerebral small vessel disease by using magnetic resonance imaging. The study may provide biomarkers for the early prevention and treatment of cerebrovascular disease. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04041349 -
Clinical Observation for the Therapeutic Effect of mNGF on Cognitive Decline in Cerebral Small Vessel Disease
|
Phase 4 | |
| Recruiting |
NCT04109963 -
Trial of Remote Ischemic Pre-conditioning in Vascular Cognitive Impairment
|
Phase 2 | |
| Not yet recruiting |
NCT05967728 -
Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke Care
|
Phase 2 | |
| Completed |
NCT05714813 -
Circuit Training and Retina
|
N/A | |
| Not yet recruiting |
NCT06077305 -
A Registry Study of Microcirculation Disorder After Cerebral Small Vessel Disease and Ischemic Stroke
|
||
| Not yet recruiting |
NCT06061692 -
Tongxinluo Capsule in the Treatment of Cerebral Small Vessel Disease-A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study（TOPS-CSVD）
|
Phase 4 | |
| Recruiting |
NCT04962295 -
China Imaging-based Biobank of Cerebral Small Vessal Diseases
|
||
| Completed |
NCT02801032 -
Effect of Tadalafil on Cerebral Large Arteries in Stroke
|
Phase 2 | |
| Not yet recruiting |
NCT05594966 -
Neuroimaging Combining Biomarkers for Identifying Long-term Cognitive Dysfunction and Delirium
|
||
| Terminated |
NCT02890888 -
Effect of Hyperbaric Oxygen on Functional Connectivity in Patients With Cerebral Small Vessel Disease
|
N/A | |
| Recruiting |
NCT04318119 -
Cerebral Small Vessel Disease Registry Study
|
||
| Recruiting |
NCT03906123 -
The Efficacy of DL-NBP in Patients With Mild Subcortical Ischemic Vascular Dementia
|
N/A | |
| Recruiting |
NCT05306834 -
Stopping Cognitive Decline and Dementia by Fighting Covert Cerebral Small Vessel Disease
|
N/A | |
| Not yet recruiting |
NCT05583266 -
Efficacy of Pentoxifylline on Cerebrovascular Function in Patients With Cerebral Small Vessel Disease(PERFORM)
|
Phase 4 | |
| Recruiting |
NCT05173896 -
Improving Cerebral Blood Flow and Cognition in Patients With Cerebral Small Vessel Disease. The ETLAS-2 Trial
|
Phase 2 | |
| Recruiting |
NCT01819441 -
Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke Patients
|
Phase 4 | |
| Recruiting |
NCT01688505 -
Visit-to-Visit Variability in Blood Pressure as a Predictor of Poor Cognitive Function
|
N/A | |
| Recruiting |
NCT04330222 -
Cambridge 7 Tesla Cerebral Small Vessel Disease Study
|
||
| Recruiting |
NCT04298866 -
White Matter Hyperintensities Subtypes in Cerebral Small Vessel Disease : 7 Tesla Ultra-high Resolution Imaging MRI
|
N/A | |
| Not yet recruiting |
NCT06328842 -
Effect of Multifunctional Nutrition Tube on Cerebral Small Vessel Disease Patients
|
N/A |