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Central Nervous System Diseases clinical trials

View clinical trials related to Central Nervous System Diseases.

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NCT ID: NCT05815836 Completed - Stroke Clinical Trials

Precision Medicine in Stroke

PROMISE
Start date: October 2013
Phase:
Study type: Observational

PROMISE aims at identifying novel diagnostic and prognostic circulating biomarkers for patients with acute stroke and at informing on crucial yet undetected pathophysiological mechanisms driving outcome after stroke by enriching all phenotypic information available from clinical routine with in-depth quantification of the circulating proteome and metabolome as well as other entities.

NCT ID: NCT05737420 Completed - Stroke Clinical Trials

Video-call Assisted Assessment of Acute Stroke in Addition to Stroke Severity Scales in a Prehospital Setting

Start date: July 6, 2023
Phase: N/A
Study type: Interventional

This study aims to investigate whether a live stream video between the on-call neurologist and the emergency medical services is feasible.

NCT ID: NCT05722756 Completed - Clinical trials for Central Nervous System Diseases

The Effect of Craniosacral Therapy as Additive Procedure.

COREHNERV
Start date: January 1, 2014
Phase:
Study type: Observational

This observational, retrospective study has shown, that the addition of craniosacral therapy to the Vojta method has improved the effects of the therapy in 6 months follow-up period. The chance for improvement was 9.42 times higher in Vojta + craniosacral group compared to the group conducted only with Vojta method. The study results suggest that the craniosacral procedure should be considered as an additive regimen to the Vojta method in the therapy of children with central coordination disorders (CCD) . More data is still needed to improve the rehabilitation process in this group of patients.

NCT ID: NCT05527288 Completed - Alzheimer Disease Clinical Trials

A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in Chinese Population

Start date: January 28, 2021
Phase: N/A
Study type: Interventional

This is a bridging study to visually and quantitatively assess PET images obtained after single application of 300 MBq [18F]florbetaben and PET scanning of patients with Alzheimer disease.

NCT ID: NCT05496985 Completed - Brain Diseases Clinical Trials

Chinese Validation of the Simplified Evaluation of CONsciousness Disorders(SECONDs)

Start date: December 20, 2021
Phase: N/A
Study type: Interventional

The aim of this study was to translate the SECONDs from French into Chinese and assess the validity and reliability of the Chinese version of the SECONDs .

NCT ID: NCT05204745 Completed - Dementia Clinical Trials

Ventriculomegaly and Gait Disturbance in the Senior Population in the Region of Västerbotten

VESPR
Start date: February 14, 2018
Phase:
Study type: Observational

Idiopathic normal pressure hydrocephalus (INPH) is a treatable disease of the elderly, typically causing gait impariment, dementia and urinary incontinence. The objective of this study is to make an epidemiological survey of INPH in Umeå, Sweden. Subjects with self-perceived gait impairments will be identified through a questionnaire. They will go through clinical examinations and have an MRI of the brain. A control population will also be investigated to enable comparisons between the populations. The main hypothesis is that the prevalence of INPH in the population is higher than what is previoulsy known.

NCT ID: NCT05202223 Completed - Alzheimer Disease Clinical Trials

Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers

Start date: January 15, 2022
Phase: N/A
Study type: Interventional

There is a need for caregiver-initiated and -implemented non-pharmacological interventions directly to and for the person with dementia, including environmental assessment and modification, as first-line treatments for behavioral and psychological symptoms of dementia (BPSD) in persons living with dementia (PLWD). Delivered via telehealth, Harmony at HOME (H@H) aims to train caregivers of persons with moderate to severe ADRD in the skills of assessing and modifying the home environment to promote "person-environment fit," a concept that posits that the ability to access features within a built environment (e.g. bathroom, stairs,) or that factors within the environment itself (lighting, noise level, temperature), especially when linked with individualized social support, contribute to or even shape behavior. In addition to the intervention, the first 10 caregiver participants to enroll will also be invited to participate in two focus groups that will be facilitated during and after the intervention. The first focus group focuses on experiences as a dementia caregiver in rural areas. The second focus group focuses on providing feedback regarding caregivers' perceptions, acceptability, and usefulness of the H@H intervention. These focus groups will be conducted as structured interviews with open-ended questions that encourage participants to share their experiences.

NCT ID: NCT05088473 Completed - Multiple Sclerosis Clinical Trials

Diagnosic and Pronostic Values of Kappa and Lambda Free Light Chains in Central Nervous System Inflammatory Diseases

Start date: October 15, 2021
Phase:
Study type: Observational

Numerous studies have shown the diagnostic interest of cerebrospinal fluid kappa free light chains and kappa index in multiple sclerosis. However, large cohort studies are lacking and little is known about the correlation between kappa and lambda indexes and multiple sclerosis evidence disease activity. Therefore, this study plan to validate the kappa and lambda free light chains and indexes as diagnostic biomarker in multiple sclerosis and to correlate the concentration of kappa and lambda free light chains with clinical and radiological activity in a large cohort of patients.

NCT ID: NCT05086874 Completed - Stroke Clinical Trials

Using Real-world Evidence to Analyze the Clinical Effects and Adverse Events of Butylphthalide in Stroke Patients

Start date: May 7, 2022
Phase:
Study type: Observational

This is a retrospective, multi-center, real-world study. The researchers plan to include 10,000 cases of ischemic stroke patients using butylphthalide and 10,000 cases of ischemic stroke patients using Edaravone. The main purpose is to analyze the effectiveness and safety of butylphthalide and establish the drug risk assessment management plan.

NCT ID: NCT05080777 Completed - Alzheimer Disease Clinical Trials

Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems

Start date: September 28, 2021
Phase: N/A
Study type: Interventional

This cluster randomized pragmatic clinical trial will test the effectiveness and feasibility of embedding the Tele-Savvy intervention, a psychoeducational program for family and other informal caregivers of older adults living in the community with Alzheimer's disease and related dementia (ADRD), in two health care systems/clinical sites: UConn Health in Farmington, Connecticut, and Emory Healthcare in Atlanta, Georgia.