Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease

Celiac Disease Clinical Trial

Official title:

Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease and Prevalence of Celiac Disease in Children With Eosinophilic Esophagitis in a Tertiary Community Hospital

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02190513
• Other study ID #: SJ 0211-07
• Status: Completed
• Phase: N/A
• First received: July 10, 2014
• Last updated: July 14, 2014
• Start date: February 2011

Study information

• Verified date: July 2014
• Source: St. John Health System, Michigan
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

Celiac disease (CD) and eosinophilic esophagitis (EE) are distinct diseases of the gastrointestinal tract with specific clinico-pathological characteristics. In recent years, in the literature, several children who underwent upper gastrointestinal endoscopy for suspected CD, which was confirmed histologically, were also found to have coexistent EE. There are reports of coexistent CD and EE. We would like to see the prevalence of EE in children with CD and the prevalence of CD in children with EE in our population, and to do so would like to review medical records. Our objectives are to determine if children with celiac disease have a high prevalence of eosinophilic esophagitis.and to determine if children with eosinophilic esophagitis have increased risk of developing celiac disease.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 56
• Est. primary completion date: June 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 2 Years to 21 Years

Eligibility

Inclusion Criteria:

• Seen in the Pediatric Gastroenterology clinic at St. John Hospital & Medical Center during study time frame

• Age 2-21 years old

• Diagnosed with CD or EE or both based on the endoscopic and histopathological findings .

Exclusion Criteria:

• Gastroesophageal reflux diagnosed by PH probe.

• History of chemical ingestion

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Celiac Disease
• Eosinophilic Esophagitis
• Esophagitis

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
St. John Health System, Michigan

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Review of histopathology reports of esophageal biopsies to record the number of eosinophils per high power field.		Retrospective chart review study, no contact made with patients, so no patient time is required, expected average of 2 years	No