Clinical Trials Logo

Clinical Trial Summary

The aim of the present study is to detect Celiac Disease among suspected patients with Type 1 Diabetes Mellitus who admitted to Assiut University Children's Hospital during one year duration


Clinical Trial Description

Type 1 diabetes mellitus (T1DM) is an immune-mediated disease characterized by reduced insulin secretion by islet Beta cells in the pancreas that leads to insulin deficiency . Because of a common genetic background and interaction between environmental and immunological factors, Patients with T1DM are at a great risk for developing autoimmune diseases. It is well recognized that T1DM can be associated with celiac disease (CD) and autoimmune thyroid disorders (ATD). Recent studies regarding CD and T1DM have indicated that the frequency of this association can vary from 1.7% to 16% . Also other autoimmune diseases may be noted such as Addison's disease and vitiligo. Celiac disease is an autoimmune enteropathy that is caused by permanent susceptibility to gluten (a protein found in wheat, barley, and rye) in genetically susceptible individuals . CD develops with symptoms, such as steatorrhea, weight loss, developmental disorder, abdominal pain, and nutritional symptoms (e.g. vitamin deficiency), and is improved shortly after elimination of gluten-containing foods . Extraintestinal signs and symptoms include iron-deficiency anemia, chronic fatigue, failure to thrive, stunted or short stature, delayed puberty, amenorrhea, recurrent aphthous stomatitis, dermatitis herpetiformis - like rash, fracture with inadequate traumas, osteopenia, osteoporosis. Since the majority of CD patients can be asymptomatic, screening for CD at the time of T1DM diagnosis is recommended . In seronegative cases at the first screening, if there are no CD symptoms, regular screening every 2-5 years is recommended. However, in patients with CD symptoms or history of CD in first-degree relatives more frequent screening is recommended . Testing of asymptomatic CD would provide a prompt diagnosis of CD and enable better metabolic control for T1DM patients . However, recently, some studies have shown normalization of celiac serology in patients with T1DM, even with no gluten-free dietary intervention. In the mentioned studies, spontaneous normalization developed in 20-35% of the cases . Therefore, considering all of the serologically positive individuals as CD and giving a gluten-free diet (GFD) imposes an additional psychological burden for children and families. In the latest European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines, it was highlighted that the level of anti-tissue transglutaminase-IgA (anti-TTG IgA) should be at least 10 times higher than the upper limit of normal (ULN) for diagnosis of CD without duodenal biopsy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05442398
Study type Observational [Patient Registry]
Source Assiut University
Contact
Status Active, not recruiting
Phase
Start date July 1, 2022
Completion date September 15, 2024

See also
  Status Clinical Trial Phase
Not yet recruiting NCT04440501 - Virtual Reality to Teach, Improve Outcomes, and Engage (VIRTUE): Virtual Reality to Improve Gluten-Free Diet Knowledge in Pediatric Celiac Disease N/A
Enrolling by invitation NCT06179121 - "Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve Early Diagnosis of Celiac Disease"
Recruiting NCT06324539 - Validation of a New Innovative Method for Specific Marker Detection in Celiac Disease
Completed NCT06359613 - Efficacy Assessment of Gluten Free Cupcakes N/A
Active, not recruiting NCT05548166 - Development of CELIAC-Q KIDS: A Patient-Reported Outcome Measure for Pediatric Celiac Disease
Recruiting NCT04014660 - Prevention av Autoimmunitet Med Laktobaciller N/A
Not yet recruiting NCT04019223 - Anti-Tissue Transglutaminase IgA Antibodies
Completed NCT03966625 - Serological Identification of Celiac Disease in Kids
Not yet recruiting NCT03244254 - Intestinal Fatty Acid-binding Protein (I-FABP) Levels in Pediatric Celiac Patients N/A
Recruiting NCT05132725 - Carbohydrate Counting and DASH Intervention Among Children With Diabetes and Celiac Disease. N/A
Enrolling by invitation NCT05084937 - Celiac Disease in Childhood-Adulthood Transition N/A
Active, not recruiting NCT04593888 - Gluten Reduction and Risk of Celiac Disease N/A
Recruiting NCT06007898 - Supporting Children and Young People to Live Well With Coeliac Disease N/A
Recruiting NCT06364735 - Entities and Variables Related to Catch-up Growth
Completed NCT04272983 - Population Study of the Prevalence of Celiac Disease and Other Gluten-dependent Disorders in Children and Adolescents
Not yet recruiting NCT06149507 - Effect of Acetaminophen Versus Ibuprofen in Treating Recurrent Apthous Ulcers in Pediatric Celiac Disease Phase 4
Completed NCT04240340 - Experiences of Disclosure in Adolescents With Coeliac Disease
Completed NCT03176095 - Celiac Disease Prevention With Probiotics N/A
Active, not recruiting NCT06038344 - Influence of a Gluten Free Food Guide on Diet Quality and Adherence to the GFD in Youth With Celiac Disease N/A
Completed NCT04533776 - Support for Adolescents With Celiac Disease N/A