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Cataract clinical trials

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NCT ID: NCT02571556 Completed - Clinical trials for Patients Having Undergone Unilateral Cataract Extraction and Implantation of a Monofocal

OPEN-LABEL, MULTI-CENTER, PHASE 1b/2a CLINICAL TRIAL DESIGNED TO EVALUATE THE SAFETY AND EFFICACY OF IONTOPHORETIC DEXAMETHASONE PHOSPHATE OPHTHALMIC SOLUTION IN PATIENTS HAVING UNDERGONE CATARACT SURGERY WITH IMPLANTATION OF A POSTERIOR CHAMBER INTRAOCULAR LENS (IOL)

Start date: November 2015
Phase: Phase 1/Phase 2
Study type: Interventional

To evaluate the safety and efficacy of ocular iontophoresis with dexamethasone phosphate ophthalmic solution, EGP-437®, using the EyeGate® II Drug Delivery System (EGDS) in patients having undergone cataract surgery with implantation of a posterior chamber intraocular lens (IOL)

NCT ID: NCT02567565 Completed - Cataract Patients Clinical Trials

Evaluation of Tear Film Lipid Layer Thickness Change After Cataract Surgery

Start date: May 2015
Phase: N/A
Study type: Observational [Patient Registry]

This study will compare cataract patients before and after phacoemulsification. Evaluations will be performed before and 1 and 3 months following cataract surgery, including measurement of tear film lipid layer thickness, tear film break up time, Schirmer test, corneal and conjunctival fluorescein staining, examination of lid margins and meibomian glands, and the Ocular Surface Disease Index.

NCT ID: NCT02566083 Completed - Cataract Clinical Trials

Post-Approval Study of the Tecnis® Toric IOL

Start date: October 21, 2015
Phase: N/A
Study type: Interventional

This study is a prospective, multicenter, bilateral, non-randomized, open-label, comparative clinical study conducted at up to 80 sites in the USA. Subjects will choose to be bilaterally implanted with either 1) the TECNIS 1-Piece Toric IOLs, Model ZCT300 and/or ZCT400, or 2) the TECNIS Monofocal Model ZCB00 non-toric control IOL, according to subject preference

NCT ID: NCT02561104 Completed - Clinical trials for Senile Nuclear Sclerosis

Resident-Performed Laser-Assisted vs Manual Traditional Phacoemulsification Cataract Surgery

Start date: December 2015
Phase: N/A
Study type: Interventional

The study design will be a prospective study comparing laser-assisted cataract extraction cases and traditional manual phacoemulsification cases. All cases will be performed by faculty-supervised residents at Parkland Memorial Hospital. This study aims to examine visual acuity and complication rates in femtosecond laser-assisted cataract surgery compared to traditional manual phacoemulsification cataract surgery for the beginning surgeon. In addition, this study will assess the subjective novice surgeon experience and the patient experience in terms of expectations and results.

NCT ID: NCT02558712 Completed - Cataract Clinical Trials

Technology-based Eye Care Services (TECS) Compare

Start date: March 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to compare the Technology-based Eye Care Services (TECS) protocol to the standard face to face ophthalmologic exam.

NCT ID: NCT02558218 Completed - Cataract Clinical Trials

Postoperative Discomfort and Ocular Redness Following Phacoemulsification Surgery

Start date: January 2015
Phase: N/A
Study type: Interventional

Primary objective of the study is the assessment of the patients' discomfort and ocular redness following cataract extraction surgery by means of phacoemulsification and intraocular lens implantation.

NCT ID: NCT02547623 Completed - Cataract Clinical Trials

Study to Evaluate the Safety for the Treatment of Inflammation Associated With Cataract Surgery

Start date: November 6, 2015
Phase: Phase 3
Study type: Interventional

The study is a prospective, randomized, parallel-design, multicenter trial in patients ≥40 years of age undergoing cataract surgery. Patients who meet all inclusion and no exclusion criteria will be randomized to 1 of 2 treatment groups - A single 5 mcl anterior chamber injection of IBI 10090, 103.4 mcg/mcl dexamethasone, equivalent dexamethasone dose: 517 mcg at the conclusion of cataract surgery or; - Prednisolone acetate ophthalmic suspension 1% eye drops administered 1 drop 4 times daily (QID) for 3 weeks Safety will be assessed by adverse events (AEs), slit lamp biomicroscopy, fundus examination, intraocular pressure (IOP), visual acuity, and specular microscopy endothelial cell count.

NCT ID: NCT02535819 Completed - Cataracts Clinical Trials

Endothelial Cell Loss After Phacoemulsification Intra and Supracapsular

PERCEPOLIS
Start date: June 2015
Phase: N/A
Study type: Interventional

Cataract is the clouding of the lens of the eye, which initially prevents clear vision and eventually progresses to blindness if left untreated. Cataract remains the leading cause of blindness and an important cause of visual impairment across the globe. Cataract surgery by ultrasonic phacoemulsification is the most common surgery practiced in France (600 000/year) Two sub-categories of phacoemulsification coexist : Endocapsulars techniques represented by Divide-and-Conquer and Phaco-Chop ; and Supracapsular techniques mainly represented by Subluxation (similar to Tilt-and-Tumble) The corneal endothelium plays an important role in maintaining the dehydrated state and the transparency of the cornea. Some degree of endothelial cell loss invariably occurs in all types of cataract surgery but the amount of endothelial cell loss may varies with the type of surgical technique The aim of the study is to evaluate the density of the central corneal endothelial cells before and after cataract surgery comparing two phacoemulsification techniques (Divide-and-Conquer vs Subluxation)

NCT ID: NCT02529488 Completed - Cataract Clinical Trials

Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00

Start date: September 7, 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate visual outcomes and assess safety at 12 months (330-420 days) post bilateral implantation of the AcrySof® IQ PanOptix™ Presbyopia-Correcting IOL.

NCT ID: NCT02526706 Completed - Glaucoma Clinical Trials

Using a Type of Blue Dye to Observe Bleb Function During Cataract Surgery

Start date: August 2015
Phase: N/A
Study type: Interventional

The investigators aim to conduct a prospective clinical pilot study to investigate the use of VisionBlue staining administered during cataract surgery to 20 patients with history of trabeculectomy for glaucoma as a means to assess functioning of an existing filtering bleb. The investigators also aim to develop a standard classification system for assessing filtering bleb function during cataract surgery.