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Clinical Trial Summary

Establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards.


Clinical Trial Description

The authors hypothesize FGF-23 and GDF-15 could predict cerebral ischemia, postoperative complications and long term major cardiovascular events, particularly in patients developing symptomatic neurologic ischemia after circulation shutdown.

Establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards.

Clarify the pathophysiology of carotid endarterectomy-related stroke and the role of GDF-15, FGF-23, BNP and hs-troponin I and other biomarkers in the prognosis of symptomatic carotid stenosis.

Imagiologic markers are to be included - intima-media; gray weale plaque classification, cerebral CT Peak wave velocity ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04327492
Study type Observational [Patient Registry]
Source Universidade do Porto
Contact Joao R Neves, MD, MSC; MPH
Phone +351910486230
Email joaorochaneves@hotmail.com
Status Not yet recruiting
Phase
Start date April 1, 2020
Completion date December 31, 2022

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