Carotid Artery Stenosis Clinical Trial
Official title:
Efficacy of Two Different Doses of Atorvastatin for Prevention of Periprocedural Ischemic Brain Damage in Chinese Patients Undergoing Carotid Artery Stenting (CAS)
The purpose is to test whether a short-term, high-dose atorvastatin treatment (80mg once a daily (QD) from 3 days before to 3 days after CAS, then 20 mg QD until 30 days after CAS) is superior to conventional-dose atorvastatin treatment (20 mg QD from 3 days before to 30 days after CAS), in terms of efficacy for prevention of periprocedural ischemic brain damage in Chinese patients undergoing CAS.
Chinese patients with carotid stenosis scheduled for selective CAS will be randomized into two groups. The High-dose Atorvastatin group will receive Atorvastatin 80 mg QD from 3 days before to 3 days after CAS, then 20 mg QD until 30 days after CAS, while the Conventional-dose Atorvastatin group will receive Atorvastatin 20 mg QD from 3 days before to 30 days after CAS. All patients will receive cerebral diffusion-weighted (DW)-MRI within 7 days before CAS. Then, they will also receive repeated DW-MRI within 5 days after CAS. Efficacy for prevention of periprocedural ischemic brain damage of the two different Atorvastatin treatments will be compared, in terms of periprocedural incidence of transient ischemic attack (TIA)/ ischaemic stroke or new ischemic lesions on cerebral DW-MRI. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT03931161 -
Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery Stenosis (EVOCAR-1)
|
Phase 4 | |
| Recruiting |
NCT03353103 -
Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy
|
Phase 2 | |
| Completed |
NCT03996148 -
Time to Post-Anesthesia Neurological Evaluation With Three Different Anesthetic Techniques
|
Phase 4 | |
| Recruiting |
NCT05968053 -
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
|
||
| Completed |
NCT00318851 -
Carotid Artery Stenting With Protection Registry
|
Phase 3 | |
| Completed |
NCT00597974 -
Neurological Outcome With Carotid Artery Stenting
|
N/A | |
| Active, not recruiting |
NCT05293067 -
Troponin In Carotid Revascularization
|
||
| Completed |
NCT03133429 -
Clinical Study to Evaluate the Safety and Effectiveness of MER® Stents in Carotid Revascularisation.
|
N/A | |
| Recruiting |
NCT01440036 -
The Correlation Between the Enzyme Paraoxigenase 1 (PON1) to Carotid Artery Atheromatous Plaque
|
N/A | |
| Completed |
NCT00417963 -
ViVEXX Carotid Revascularization Trial (VIVA)
|
Phase 3 | |
| Completed |
NCT00177346 -
A Randomized Trial of Carotid Artery Stenting With and Without Cerebral Protection
|
N/A | |
| Recruiting |
NCT05574972 -
Timing Carotid Stent Clinical Study for the Treatment of Carotid Artery Stenosis（Timing Trial）
|
N/A | |
| Recruiting |
NCT02476396 -
Structural Stability of Carotid Plaque and Symptomatology
|
||
| Completed |
NCT05451485 -
VFI in Healthy Vessels
|
||
| Recruiting |
NCT06033963 -
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Carotid Artery Stenosis Receiving Carotid EndArterectomy
|
N/A | |
| Not yet recruiting |
NCT02224209 -
Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis
|
Phase 4 | |
| Completed |
NCT02006095 -
Neuroimaging Correlates of Memory Decline Following Carotid Interventions
|
||
| Terminated |
NCT01236508 -
Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease
|
Phase 4 | |
| Recruiting |
NCT05126238 -
A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction
|
Phase 3 | |
| Recruiting |
NCT06170580 -
Improved Image Quality for Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound FLOW Imaging
|