Lectine Pathway in Unstable Carotid Plaque

Status Withdrawn

Clinical Trial Summary

The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical neurologic features.

Clinical Trial Description

In addition to the known hemodynamic criteria, instable carotid plaques can be responsible for brain ischemia, therefore is paramount to identify preoperatively possible markers of plaque instability. The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical neurologic features. Study population will include 40 patients with internal carotid artery stenosis >=70% (assessed by echocolordoppler), symptomatic or asymptomatic, surgically treated by endoarterectomy. Removed plaques will be evaluated by histologic exam and immunofluorescence for ficolins 1-2-3 and Mannose Binding Lectin (MBL). Plasma samples will be used for ELISA test of lectin pathway complement activation. ;

Study Design

Related Conditions & MeSH terms

Carotid Artery Plaque
Carotid Stenosis
Mannose-Binding Lectin Complement Pathway

Clinical Trial Details

NCT number	NCT03822195
Study type	Observational
Source	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact
Status	Withdrawn
Phase
Start date	April 1, 2019
Completion date	February 28, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02224339` - New Technologies to Determine Carotid Plaque Vulnerability
Recruiting	`NCT05549336` - Single-center, Prospective Cohort Study of PD-1 Inhibitors on Clinical Outcomes of Carotid Plaques in Tumor Patients
Recruiting	`NCT05123287` - A Perspective, Self-control Study on the Progression of Carotid Plaques in Anti-PD-1 mAb Treated Tumor Patients by Artery Ultrasound Follow-up
Recruiting	`NCT04679727` - The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study
Recruiting	`NCT02476396` - Structural Stability of Carotid Plaque and Symptomatology
Completed	`NCT02947360` - The FOVUS-ER Study: Focused Vascular Ultrasound to Risk Stratify Patients With Chest Pain in the ER	N/A
Completed	`NCT03335033` - New Technologies to Determine Carotid Plaque Vulnerability in Patients With Significant Carotid Plaques	Phase 2
Recruiting	`NCT05029661` - Ultrasound Elastography for Individual Carotid Plaque Stratification
Not yet recruiting	`NCT05622877` - The Proteomic Study and Early Intervention Study of Carotid Unstable Plaque	Phase 1
Not yet recruiting	`NCT03072225` - Study on Vulnerable Plaque of Carotid Artery With Chinese Herbal and Insects Medicine	Phase 2
Recruiting	`NCT04073797` - PET Imaging of Inflammation and Lipid Lowering Study	N/A
Recruiting	`NCT04470687` - Ultrafast Ultrasound Imaging Assesment of Carotid Plaque Neovascularization	N/A
Completed	`NCT05566080` - Preoperative Identification of the Histologically "Vulnerable" Plaque Using Non-invasive Imaging, Biomechanical Assessment and Baroreflex Evaluation in Patients With Severe Carotid Stenosis
Active, not recruiting	`NCT04913493` - Use of Sublingual Microcirculation and FloTrac Monitoring During Major Vascular Surgery and Its Effect on Hospital LOS	N/A
Completed	`NCT03982420` - The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation
Completed	`NCT05134493` - Embolic Signals Detection Study (Esds) in Candidates for Surgical Carotid Revascularisation
Terminated	`NCT02667457` - 99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis	Phase 2
Recruiting	`NCT04063709` - Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke Risk	N/A
Completed	`NCT04318171` - The Evaluation of Tomographic 3D Ultrasound for the Assessment of Vascular Pathology
Completed	`NCT04835571` - CARotid Mri of Atherosclerosis	N/A