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Caries clinical trials

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NCT ID: NCT06140758 Completed - Caries Clinical Trials

Evaluation of the Anticaries Efficacy of Dentifrice Formulations Using an In-situ Model

Start date: July 31, 2023
Phase: N/A
Study type: Interventional

The primary objective is to compare the remineralization and demineralization inhibition potential of early subsurface carious lesions in enamel in situ after rinsing with six different aqueous slurries of toothpaste formulations.

NCT ID: NCT06140745 Completed - Caries Clinical Trials

Evaluation of Dentifrice Formulations to Remineralize Enamel and Dentine Subsurface Lesions in a Double-Blind In-Situ Clinical Trial

Start date: October 5, 2020
Phase: N/A
Study type: Interventional

To compare the remineralization and demineralization inhibition potential of early subsurface carious lesions in enamel in situ after rinsing with five different aqueous slurries of toothpaste formulations. Percent remineralization (%R), i.e. the % change in ΔZ values relative to ΔZd, will be the primary outcome measure.

NCT ID: NCT06081816 Completed - Clinical trials for Periodontal Diseases

Third Molar: Caries, Periodontal Desease and Quality of Life

Start date: May 1, 2013
Phase:
Study type: Observational [Patient Registry]

Caries and periodontal disease are chronic diseases of the oral cavity. The incidence of caries and periodontal disease can vary depending on the position of the third molar, The aim of this study was to verify possible associations between oral health-related quality of life (QoL), periodontal disease, caries lesions and the position of the lower third molar.

NCT ID: NCT06072742 Completed - Inflammation Clinical Trials

Effect of Lifestyle on Caries and Apical Periodontitis

Start date: September 20, 2020
Phase:
Study type: Observational [Patient Registry]

This study aimed to link lifestyle factors (Mediterranean diet adherence, stress, sleep quality, physical activity) to caries and apical periodontitis in 149 university-based individuals. Data included clinical and radiographic assessments and lifestyle questionnaires. Statistical tests and logistic regression were employed to analyze the relationships between these factors and oral health conditions.

NCT ID: NCT06010732 Completed - Caries Clinical Trials

In Situ Comparison of the Remineralization Potential of Optimized Fluoride Dentifrice With Control Fluoride Dentifrice

Start date: October 2, 2023
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the remineralization potential of an optimized fluoride dentifrice to a control fluoride dentifrice in an in situ caries model.

NCT ID: NCT05212142 Completed - Caries Clinical Trials

A Strategy to Prevent the Recurrence of Dental Disease in Children Receiving Dental Treatment With General Anesthesia

Start date: June 10, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effectiveness of a preventive strategy in increasing return to follow up and recall appointments.

NCT ID: NCT05178823 Completed - Caries Clinical Trials

Short- and Long Term Antibacterial Effects of a Single Rinse With Different Mouthwashes: a Randomized Clinical Trial

Start date: June 1, 2017
Phase: Phase 4
Study type: Interventional

Objectives: To reduce the microbial level in the aerosol created during dental procedures is essential in avoiding infections. The aim of this study was to examine the change of Streptococcus mutans (S. mutans) and the total bacterial load in human saliva in vivo after a single rinse with different mouthwashes. Material and methods: One mL unstimulated saliva was collected from volunteers with poor oral hygiene at baseline and 5 min after a one-min rinsing with Solumium Oral® (hyper-pure 0.0015% chlorine dioxide; ClO2), Listerine Total Care®, Corsodyl® (0.2% chlorhexidine-digluconate; CHX), or BioGate Si*CLEAN for bacterial investigation. In a second study volunteers rinsed with 0.003% ClO2 or CHX for one-min and saliva was collected at baseline, after 5 and 90 min. After plating the total plate and S. mutans colony numbers were determined.

NCT ID: NCT04973761 Completed - Caries Clinical Trials

Quality of Life for Children With Zirconium Anteroir Crowns Versus Strip Composite Crowns

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

Early Childhood Oral Health Impact Scale (ECOHIS) will be used for detection of oral health related quality of life for children using strip composite crowns versus zirconium crowns at 6 and 12 months

NCT ID: NCT04906291 Completed - Caries Clinical Trials

The Preventive Effect of 2-years Use of Hydroxyapatite Containing Toothpastes in Children.

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

The aim of this RCT was to verify the caries preventive efficacy of toothpastes containing biomimetic hydroxyapatite (H.A.) complex in children compared to traditional fluoridated toothpastes. In total 610 children of two age groups (4-5 years and 6-7 years at baseline) were enrolled. Four toothpastes, two containing fluoride-substituted hydroxyapatite (H.A.F.) (1000 and 1450 ppm F-) and magnesium-, strontium-, carbonate-substituted hydroxyapatite, in a chitosan matrix and two traditional fluoridated toothpastes (1000 and 1450 ppm F-) without other active components were administered randomly to two groups with younger children (Gyoung) and to two groups with older children those containing1450 ppm F (GOLD) during 24 months. A standardized questionnaire was administered to parents/caregivers to gain information regarding caries risk factors. Caries evaluation was performed at school using ICDAS, scoring lesions as initial (up to score 2), moderate (scores 3-4) and severe (scores 5-6).

NCT ID: NCT04763044 Completed - Caries Clinical Trials

Evaluation of the Fluoride Dose Response Using In Situ Caries Model

Start date: March 1, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the fluoride dose response of different dentifrice fluoride concentrations - 0, 250, 1100 and 2800 ppm fluoride as sodium monofluorophosphate (MFP) and a fifth leg of 1100 ppm Stannous Fluoride (SnF2) using an in situ caries model.