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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05275127
Other study ID # 215/21/PO
Secondary ID
Status Completed
Phase
First received
Last updated
Start date March 14, 2022
Est. completion date November 20, 2022

Study information

Verified date April 2023
Source University of Catania
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA 200b-5p and their correlation with periodontitis extent.


Description:

The patients selected for the study were divided into 2 groups: group 1 (FM-SRP), group 2 (Q-SRP). Any selected subject underwent anamnestic and periodontal examination, blood and GCF sampling. MiRNA in the GCF was extracted through a commercially available kit and then measured carrying out real-time quantitative polymerase chain reaction (RT-PCR).


Recruitment information / eligibility

Status Completed
Enrollment 89
Est. completion date November 20, 2022
Est. primary completion date November 15, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria: - Presence of at least 15 teeth - CP with a minimum of 40% of sites with a clinical attachment level (CAL) =2mm and probing depth (PD) =4mm; - Presence of at least =2 mm of crestal alveolar bone loss verified on digital periapical radiographs - Presence of =40% sites with bleeding on probing (BOP) Exclusion Criteria: - Intake of contraceptives - Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study - Status of pregnancy or lactation - Previous history of excessive drinking - Allergy to local anaesthetic - Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
changes of gingival crevicular fluid miRNA
Evaluation of changes of gingival crevicular fluid miRNA after periodontal treatment

Locations

Country Name City State
Italy University of Catania Catania CT

Sponsors (1)

Lead Sponsor Collaborator
University of Catania

Country where clinical trial is conducted

Italy, 

Outcome

Type Measure Description Time frame Safety issue
Primary Clinical attachment level reduction evaluation of millimeters reduction of clinical attachment level (CAL) after periodontal therapy 1-year
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