Cardiovascular Diseases Clinical Trial
Official title:
Analysis of Gingival Crevicular Fluid miRNA Changes After Periodontal Treatment.
NCT number | NCT05275127 |
Other study ID # | 215/21/PO |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | March 14, 2022 |
Est. completion date | November 20, 2022 |
Verified date | April 2023 |
Source | University of Catania |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA 200b-5p and their correlation with periodontitis extent.
Status | Completed |
Enrollment | 89 |
Est. completion date | November 20, 2022 |
Est. primary completion date | November 15, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - Presence of at least 15 teeth - CP with a minimum of 40% of sites with a clinical attachment level (CAL) =2mm and probing depth (PD) =4mm; - Presence of at least =2 mm of crestal alveolar bone loss verified on digital periapical radiographs - Presence of =40% sites with bleeding on probing (BOP) Exclusion Criteria: - Intake of contraceptives - Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study - Status of pregnancy or lactation - Previous history of excessive drinking - Allergy to local anaesthetic - Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs. |
Country | Name | City | State |
---|---|---|---|
Italy | University of Catania | Catania | CT |
Lead Sponsor | Collaborator |
---|---|
University of Catania |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinical attachment level reduction | evaluation of millimeters reduction of clinical attachment level (CAL) after periodontal therapy | 1-year |
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