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In Vivo Glycocalyx as Predictor of Complications After Cardiac Surgery — GLYPOCS  

Cardiovascular Diseases Clinical Trial

Official title:
Glycocalyx as Predictor of Complications After Cardiac Surgery

Clinical Trial Summary

Cardiac surgery has been described as altering endothelium structure and function, notably because of the use of cardiac-pulmonary bypass (CPB). Among the endothelial structure, glycocalyx, the thin layer recovering the endothelial surface, may be altered by the inflammatory process and probably the modification of flow during CPB. Endothelial and glycocalyx integrity are essential for vascular function and glycocalyx destruction is associated with organ failure and mortality. On the other hand, a chronic alteration of glycocalyx is observed in many diseases such as diabetes, hypertension or chronic kidney failure, all pathologies frequently observed in patients benefiting grom cardiac surgery. Thus the preoperative alteration of glycocalyx may be associated with postoperative organ failure.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04643535
Study type Observational
Source University Hospital, Rouen
Contact Emmanuel Besnier, MD PhD
Phone +33232881705
Email emmanuel.besnier@chu-rouen.fr
Status Recruiting
Phase
Start date November 30, 2020
Completion date December 30, 2023
View Details
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