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NCT04108182 Clinical Trial

A Registry Study of Biomarkers in Progression of Acute Heart Failure(BIOMS-POAHF)

Cardiovascular Diseases Clinical Trial

Official title:
A Registry Study of Biomarkers in Progression of Acute Heart Failure

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04108182
Other study ID # BIOMS-POAHF
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date December 2015
Est. completion date October 2025

Study information
Verified date September 2019
Source Beijing Institute of Heart, Lung and Blood Vessel Diseases
Contact Yulin Li, PHD
Email lyllyl_1111@163.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The registry study aims to discover the prognostic value of bio-markers in acute heart failure

Recruitment information / eligibility
Status Recruiting
Enrollment 850
Est. completion date October 2025
Est. primary completion date August 2025
Accepts healthy volunteers
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- 1. Patients aged greater than or equal to 18 years with acute exacerbation of chronic heart failure or new heart failure

- 2. With typical symptoms of acute heart failure as follows: Dyspnea, ankle swelling and fatigue (Limited activity endurance), increased jugular pressure, rales and peripheral edema ;

- 3. Plasma concentrations of BNP: BNP>100pg/ML

- 4. Echocardiography: Related structural heart disease (left ventricular hypertrophy and/or left atrial enlargement) and/or diastolic dysfunction

Exclusion Criteria:

- 1. Previous history of cancer or renal replacement therapy

- 2.Surgery was performed within a month

- 3.Accompanied by cardiogenic shock, sepsis, pneumonia

- 4.Eligible patients without informed consent form

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
China Beijing Anzhen Hospital Beijing

Sponsors (1)
Lead Sponsor Collaborator
Beijing Institute of Heart, Lung and Blood Vessel Diseases

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of death ( all cause) or readmission for heart failure Number of Death or heart failure related hospitalization within a median follow-up of 8.8 months of discharge a median follow-up of 8.8 months
Secondary Number of death ( all cause) or readmission for heart failure and cardiovascular mortality Number of Death or heart failure related hospitalization and cardiovascular mortality within a median follow-up of 8.8 months of discharge a median follow-up of 8.8 months
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