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Clinical Trial Summary

Plant stanols are known to lower low-density lipoprotein cholesterol. However, studies have suggested that these compounds also influence the immune system. Asthmatic responses are predominantly T helper (Th)2 cell dependent, while plant stanols were previously found to activate Th1 cells and shift the immune response away from the Th2 cell dominant asthmatic response. The question now is whether this also translates into a reduction of clinical symptoms in asthma patients.The primary objective of this study is to demonstrate clinical benefits of prolonged consumption of plant stanols (delivered via plant stanol esters) in asthma patients. The secondary objectives are to evaluate the mechanisms via which plant stanols modulate the immune system and to evaluate the effects of plant stanol ester consumption on cardiovascular (CVD) risk parameters.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03983603
Study type Interventional
Source Maastricht University Medical Center
Contact Jogchum Plat, PhD
Phone +31433881309
Email j.plat@maastrichtuniversity.nl
Status Recruiting
Phase N/A
Start date April 29, 2019
Completion date September 2024

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