Cardiovascular Diseases Clinical Trial
Official title:
Primary Ovarian Insufficiency, Polycystic Ovary Syndrome & the CardiOvascular Risk Profile
The polycystic ovary syndrome (PCOS) is the most common endocrinopathy amongst women of
reproductive age. PCOS is associated with various cardiovascular risk factors such as
obesity, glucose intolerance, dyslipidemia hypertension and the metabolic syndrome. Whether
these increased cardiovascular risk factors result in the development of actual
cardiovascular disease in later life remains to be established.
Women with premature ovarian insufficiency (POI), experience menopause prior to the age of 40
years. Women with POI may exhibit dyslipidemia. A young age at menopause has been previously
associated with increased cardiovascular morbidity and mortality.
Cardiovascular risk profile will be assessed in women with PCOS and POI > 45 years of age,
consisting of:
fasting serum and urine analyses blood pressure, length, weight, waist circumference, hip
circumference ECG carotid intima media thickness cardiac ultrasound
spare serum, plasma and urine will be stored in -80 degrees celsius biobank.
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