Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT00626379 |
| Other study ID # |
1379 |
| Secondary ID |
R01HL081141-04 |
| Status |
Completed |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
November 2007 |
| Est. completion date |
December 2010 |
Study information
| Verified date |
May 2023 |
| Source |
Northwestern University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Heart disease is the leading cause of death in the United States and is responsible for 30%
of all deaths in the United States. This study will examine how risk factors for heart
disease in young and middle aged people affect people's health as they grow older.
Description:
Heart disease, including coronary heart disease (CHD) and cardiovascular disease (CVD), is a
serious health problem in the United States. It is the leading cause of death in this
country, and each year almost 700,000 people die from the disease. Risk factors for heart
disease include high blood pressure, high cholesterol levels, tobacco use, diabetes, and
history of a prior heart attack. It has been shown that young and middle aged adults with few
risk factors experience a lower incidence of heart disease, lower Medicare costs, and longer
lives than those with more risk factors. However, it is not known how having a low risk for
heart disease at a young age affects health-related outcomes in older age. It may be possible
that a low risk for developing heart disease in younger years results in healthier aging than
does a higher risk. This study will examine former participants of the Chicago Heart
Association (CHA) study who are now 65 to 84 years old. The purpose of this study is to
determine how risk factors for heart disease in young adulthood and middle age are related to
healthy aging.
This study will enroll 1500 people who participated in the CHA study from 1967 to 1973 and
who are still living in the Greater Chicagoland area. Six hundred former participants who had
a low risk of developing heart disease and 900 former participants who had a high risk of
developing heart disease will be enrolled. Participants will attend one study visit that will
include medical history interviews and questionnaires, a physical examination, blood pressure
measurements, blood and urine collection, and an electrocardiogram (ECG) to measure the
electrical activity of the heart. Blood samples will be collected and stored for future
genetic testing. Participants will undergo physical functioning performance tests on balance,
leg strength and coordination, grip strength, and endurance. They will also undergo a
computed tomography chest scan to measure the amount of calcium in the arteries of the heart
and ultrasound scans of the arteries in the neck to measure artery size and function.
