Cardiovascular Diseases Clinical Trial
Official title:
Follow-up Study of Hyperthyroid Patients Treated With RAI in 1965-2002: Morbidity in Long-Term Follow-up
Previous studies of hyperthyroid patients suggest that they remain at increased risk of
cardiovascular morbidity after restoring euthyroidism.
The study objective is to compare the rate and causes of hospitalization of hyperthyroid
patients treated with radioactive iodine (RAI) with those of an age- and gender-matched
reference population in a long-term follow-up study.
A population-based cohort study was conducted among 2611 hyperthyroid patients treated with
RAI between 1969 and 2002 in Tampere University Hospital, and among 2611 reference subjects.
A reference group was randomly selected, with an age- and gender-matched control subject
identified for each patient from the Population Register Centre. The control subject had to
be alive at the time when the patient received the first RAI treatment.
The causes of hospitalization as well as the diagnosis and date of hospital admission were
obtained from the nationwide Hospital Discharge Register (HILMO) maintained by the Research
and Development Centre for Welfare and Health (STAKES) using a computerized record linkage,
with the personal identification number as the key. The HILMO database covers all dates and
causes of hospitalization (hospital admission requiring an overnight stay) of the Finnish
citizens since January 1969. New events were analyzed as the main outcome, including only
the first hospitalization due to a given indication. The special focus was on the
cardiovascular morbidity.
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Observational Model: Defined Population, Time Perspective: Longitudinal
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