Gene Mapping for Quantitative Traits

Cardiovascular Diseases Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00005535
• Other study ID #: 5068
• Secondary ID: R01HL055976
• Status: Completed
• Phase: N/A
• First received: May 25, 2000
• Last updated: February 17, 2016
• Start date: September 1995
• Est. completion date: August 2000

Study information

• Verified date: October 2002
• Source: National Heart, Lung, and Blood Institute (NHLBI)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

To conduct gene mapping studies for quantitative traits.

Description:

DESIGN NARRATIVE:

The study built upon existing sib-pair methods for multipoint mapping of Quantitative Trait Loci (QTL)s. It greatly expanded upon the statistical methodology to identify and localize QTLs for complex traits by merging sib-pair methods with a powerful twin design which used phenotypic data on monozygotic (identical) and dizygotic (fraternal) twins to resolve phenotypic variability into genetic and non-genetic components, and partition human quantitative genetic variation into effects due to loci on specific chromosomal regions. This quantitative methodology was applied to risk factors for cardiovascular disease -- one of the most pressing health problems in Western society. Population-based samples of Dutch, Swedish, and Australian twins had been identified in previous studies, phenotypic measures on lipids, lipoproteins, and other important cardiovascular risk factors had been obtained, and blood had been banked in a valuable resource which was available for use in this study. In 500 DZ twin pairs, a series of 175 highly polymorphic microsatellite markers were detected using an automated process for detecting fluorescent signals. These data were analyzed using the new statistical methods both to confirm the effects of a series of candidate loci and to test for the effects of previously unknown QTLs.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: August 2000
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A to 100 Years
• Eligibility: No eligibility criteria

Study Design

N/A

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Heart Diseases

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
National Heart, Lung, and Blood Institute (NHLBI)

References & Publications (6)

Beekman M, Heijmans BT, Martin NG, Pedersen NL, Whitfield JB, DeFaire U, van Baal GC, Snieder H, Vogler GP, Slagboom PE, Boomsma DI. Heritabilities of apolipoprotein and lipid levels in three countries. Twin Res. 2002 Apr;5(2):87-97. — View Citation

Beekman M, Lakenberg N, Cherny SS, de Knijff P, Kluft CC, van Ommen GJ, Vogler GP, Frants RR, Boomsma DI, Slagboom PE. A powerful and rapid approach to human genome scanning using small quantities of genomic DNA. Genet Res. 2001 Apr;77(2):129-34. — View Citation

McClearn GE, Vogler GP. Genetics and behavioral medicine: the error of the error term. Behav Med. 1997 Winter;22(4):150-1. — View Citation

Nelson TL, Vogler GP, Pedersen NL, Miles TP. Genetic and environmental influences on waist-to-hip ratio and waist circumference in an older Swedish twin population. Int J Obes Relat Metab Disord. 1999 May;23(5):449-55. — View Citation

Vogler GP, McClearn GE, Snieder H, Boomsma DI, Palmer R, de Knijff P, Slagboom PE. Genetics and behavioral medicine: risk factors for cardiovascular disease. Behav Med. 1997 Winter;22(4):141-9. Review. — View Citation

Vogler GP, Tang W, Nelson TL, Hofer SM, Grant JD, Tarantino LM, Fernandez JR. A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits. Genet Epidemiol. 1997;14(6):921-6. — View Citation