Cardiovascular Diseases Clinical Trial
To analyze data collected over a four year period on an initial cohort of 3 or 4 year old children and their parents in Galveston, Texas, and in Augusta, GA, in regard to cardiovascular disease (CVD) physical risk factors and risk related behaviors.
BACKGROUND:
Little was known about tracking of cardiovascular disease (CVD) risk factors and risk
related behaviors, or about predicting these variables in young children. Tracking was an
important issue because it reflected the extent to which the disease processes found among
adults start in childhood, and whether behavioral or social factors could be used to
interrupt that tracking.
DESIGN NARRATIVE:
In Texas, physical risk factor data were collected at four annual clinics. Data on
childrens' physical activity and diet were collected for up to four times per year for the
three years between the annual measurement clinics. Similar data, although with some
different measurement techniques, were collected in Georgia. For this data analysis,
specific longitudinal research questions addressed whether these physical risk factors
(blood pressure, lipids, lipoproteins and body composition) and risk related behaviors (diet
and physical activity) tracked across the annual assessments, whether a variety of
behavioral and social factors (demographic characteristics and family function) affected
that tracking, and whether relationships obtained among adults between physical risk factors
and these other variables could be found in this age child. The testing of these
relationships was enhanced by the availability of multiple assessments of blood pressures
and body composition at each point for more reliable assessments, and by multiple
assessments of diet and physical activity within each year. It was further enhanced by the
availability of observational data on physical activity and diet, which overcame the
limitations of the more common self report approach to measurement. Models were developed in
each data set and cross validated in the other. Procedures were employed to determine
reasons for differences and to revise the models to produce maximal fit in both data sets.
The results of these analyses contributed to a better understanding of at what age, and with
what factors, it was most appropriate to intervene to mitigate CVD.
;
N/A
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
| Recruiting |
NCT05650307 -
CV Imaging of Metabolic Interventions
|
||
| Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
| Completed |
NCT04056208 -
Pistachios Blood Sugar Control, Heart and Gut Health
|
Phase 2 | |
| Recruiting |
NCT04417387 -
The Genetics and Vascular Health Check Study (GENVASC) Aims to Help Determine Whether Gathering Genetic Information Can Improve the Prediction of Risk of Coronary Artery Disease (CAD)
|
||
| Not yet recruiting |
NCT06211361 -
Cardiac Rehabilitation Program in Patients With Cardiovascular Disease
|
N/A | |
| Not yet recruiting |
NCT06032572 -
Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)
|
N/A | |
| Recruiting |
NCT04514445 -
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.
|
||
| Enrolling by invitation |
NCT04253054 -
Chinese Multi-provincial Cohort Study-Beijing Project
|
||
| Completed |
NCT03273972 -
INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers
|
N/A | |
| Completed |
NCT03680638 -
The Effect of Antioxidants on Skin Blood Flow During Local Heating
|
Phase 1 | |
| Recruiting |
NCT04843891 -
Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.
|
Phase 1 | |
| Completed |
NCT04083846 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of High-dose CKD-385 in Healthy Volunteers(Fed)
|
Phase 1 | |
| Completed |
NCT04083872 -
Clinical Study to Investigate the Pharmacokinetic Profiles and Safety of Highdose CKD-385 in Healthy Volunteers(Fasting)
|
Phase 1 | |
| Completed |
NCT03466333 -
Postnatal Enalapril to Improve Cardiovascular fUnction Following Preterm Pre-eclampsia
|
Phase 2 | |
| Completed |
NCT03619148 -
The Incidence of Respiratory Symptoms Associated With the Use of HFNO
|
N/A | |
| Completed |
NCT03693365 -
Fluid Responsiveness Tested by the Effective Pulmonary Blood Flow During a Positive End-expiratory Trial
|
||
| Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
| Completed |
NCT05132998 -
Impact of a Comprehensive Cardiac Rehabilitation Program Framework Among High Cardiovascular Risk Cancer Survivors
|
N/A | |
| Completed |
NCT05067114 -
Solutions for Atrial Fibrillation Edvocacy (SAFE)
|