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Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population — PPSIII  

Cardiovascular Disease Clinical Trial

Official title:
Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population. The Paris Prospective Study III

Clinical Trial Summary

The aim of the present PPS3 study is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

Clinical Trial Description

Overall, 10 000 men and women will be recruited during two years for an extensive clinical examination including a 2h holter ECG, a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Thereafter, the cardiovascular morbidity and mortality of the participants will be followed up for 10 years at least. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00741728
Study type Observational
Source Institut National de la Santé Et de la Recherche Médicale, France
Contact Xavier Jouven, MD, PhD
Phone 1 56 09 36 87
Email xavier.jouven@egp.aphp.fr
Status Recruiting
Phase N/A
Start date June 2008
Completion date December 2019
View Details
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