Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03274869
Other study ID # EMC 2017-07-006-001
Secondary ID
Status Completed
Phase
First received
Last updated
Start date September 1, 2017
Est. completion date August 30, 2023

Study information

Verified date February 2024
Source Eulji University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death could be a fetal complicating cardiovascular disease. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection.


Description:

Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea.


Recruitment information / eligibility

Status Completed
Enrollment 100
Est. completion date August 30, 2023
Est. primary completion date August 30, 2023
Accepts healthy volunteers
Gender All
Age group 19 Years and older
Eligibility Inclusion Criteria: - any participants with scrub typhus infection Exclusion Criteria: - patients under age of 18 - pregnancy

Study Design


Intervention

Other:
No intervention
No intervention

Locations

Country Name City State
Korea, Republic of Chung-Buk University Hospital Chungju Chung Chung Do
Korea, Republic of Chung-Nam University Hospital Daejeon Chung Chung Do

Sponsors (3)

Lead Sponsor Collaborator
Eulji University Hospital Chungbuk National University Hospital, Chungnam National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

References & Publications (3)

Chin JY, Kang KW, Moon KM, Kim J, Choi YJ. Predictors of acute myocarditis in complicated scrub typhus: an endemic province in the Republic of Korea. Korean J Intern Med. 2018 Mar;33(2):323-330. doi: 10.3904/kjim.2016.303. Epub 2017 Feb 23. — View Citation

Jang SY, Kang KW, Kim JH, Kim B, Chin JY, Park SH, Choi YJ, Jung KT, Lee SK. New-onset atrial fibrillation predicting for complicating cardiac adverse outcome in scrub typhus infection. Clin Cardiol. 2019 Dec;42(12):1210-1221. doi: 10.1002/clc.23276. Epub — View Citation

Kang KW, Hong KW, Lee SK. Identification of novel variants for complicating cardiac disease in the scrub typhus infection using whole genome sequencing. Korean J Intern Med. 2023 Nov;38(6):865-871. doi: 10.3904/kjim.2023.221. Epub 2023 Nov 1. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Cardiovascular Mortality Cardiovascular death including sudden cardiac death one year
Secondary Cardiovascular Complications Atrial Fibrillation, Acute Heart Failure including acute myocarditis and Ischemic Heart Dease one year
See also
  Status Clinical Trial Phase
Recruiting NCT05243446 - Cardiorenal Effecs of Losartan in Kidney Transplant Recipients
Completed NCT06089226 - Parameters Related to Physical Activity Level in SCI
Recruiting NCT04696081 - Atrial Fibrillation in Active Cancer Patients
Completed NCT05687097 - Untreated Sleep Apnea as an Aggravating Factor for Other Secondary Medical Conditions After Spinal Cord Injury
Completed NCT04025086 - Perioperative Goal Directed Therapy (PGDT) in Spinal Surgery in the Prone Position
Completed NCT03010969 - Perioperative Endothelial Dysfunction in Patients Undergoing Major Acute Abdominal Surgery
Completed NCT01413815 - Effect of the Amino Acid L-arginine on Perioperative Cardio-vascular Risk in Non-selected Patients N/A
Recruiting NCT05077748 - An 18-year Follow-up Study on OSA in a Population-based Cohort
Not yet recruiting NCT06279000 - Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery Phase 3
Enrolling by invitation NCT06360666 - Clinical Outcomes in Adult Patients Undergoing Laparoscopic Surgery Under Neuraxial Anesthesia
Recruiting NCT03977337 - Perioperative Pulmonary Monitoring in Major Emergency Surgery
Recruiting NCT05996965 - Evaluation of Clinical Utility of Non-invasive Hemodynamic Monitoring Device
Recruiting NCT05349955 - Effects and Safety of Diabetic GUideline Algorithm Implementation Performed by Primary Care Physicians in the Community N/A
Withdrawn NCT04435015 - The Utility of Camostat Mesylate in Patients With COVID-19 Associated Coagulopathy (CAC) and Cardiovascular Complications Phase 1/Phase 2
Active, not recruiting NCT05745090 - N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP) in Type 2 Diabetes Mellitus
Terminated NCT03760159 - Minimally Invasive Detection of a Sleep Apnoea
Completed NCT04802122 - Induction of Anesthesia With Sevoflurane Preserving Spontaneous Breathing: Cardiorespiratory Effects. Phase 4
Not yet recruiting NCT06419270 - Cardiovascular, Renal, and Skeletal Complications in Patients With Post-Surgical Hypoparathyroidism
Recruiting NCT05895669 - Cardiovascular Outcomes in Orthotopic Liver Transplanted Patients (COLT Study)
Completed NCT05685979 - Evaluation of Cardiac Functions in Deep Trendelenburg Position