Cerebral Oximetry in Cardiac Surgery to Reduce Neurological Impairment and Hospital Length-of-stay

Cardiac Surgery Clinical Trial

Official title: Cerebral Oximetry in Adult Cardiac Surgery to Reduce the Incidence of Neurological Impairment and Hospital Length-of-stay: A Prospective, Randomized, Controlled Trial

Status Completed

Clinical Trial Summary

Cerebral oximetry using near-infrared spectroscopy (NIRS) has been shown to reduce the incidence of neurological dysfunction and hospital length-of-stay in adult cardiac surgery though not all studies agree. A previous audit using cerebral saturations at or above baseline showed improved neurological and length-of-stay outcomes.

Clinical Trial Description

This prospective, single centre, double-blinded controlled study randomized 182 consecutive patients, scheduled for cardiac surgical procedures using cardiopulmonary bypass. Participants were randomized by concealed envelope prior to anaesthesia. NIRS study group were managed perioperatively using our NIRS protocol. The control group had standard management without NIRS. Primary outcomes were post-operative neurological impairment and hospital length-of-stay. Secondary outcomes included ventilation times, intensive care unit length-of-stay, major organ dysfunction and mortality ;

Related Conditions & MeSH terms

• Brain Ischemia
• Cardiac Surgery
• Cerebral Infarction
• Cerebral Ischemia
• Ischemia
• Neural Injury

• NCT number: NCT04463563
• Study type: Interventional
• Source: Hull University Teaching Hospitals NHS Trust
• Status: Completed
• Phase: N/A
• Start date: February 1, 2011
• Completion date: September 1, 2014