Cardiac Arrest Clinical Trial
— PROPEA3Official title:
Assessment of Hypoxic Brain Injury by Analyzing Propofol-induced EEG Changes
NCT number | NCT03485781 |
Other study ID # | 302/2016 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | October 12, 2017 |
Est. completion date | July 10, 2019 |
Verified date | March 2020 |
Source | University of Oulu |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
PROPEA3 is a prospective observational study investigating the recovery of propofol-induced EEG slow-wave activity and its association with neurological outcome after cardiac arrest.
Status | Completed |
Enrollment | 102 |
Est. completion date | July 10, 2019 |
Est. primary completion date | July 10, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Comatose patients admitted to intensive care after cardiac arrest Exclusion Criteria: - Previous neurological disease expected to affect EEG substantially |
Country | Name | City | State |
---|---|---|---|
Finland | Helsinki University Central Hospital | Helsinki | |
Finland | Oulu University Hospital | Oulu |
Lead Sponsor | Collaborator |
---|---|
University of Oulu | Cerenion Oy, Helsinki University Central Hospital, Oulu University Hospital |
Finland,
Kortelainen J, Väyrynen E, Huuskonen U, Laurila J, Koskenkari J, Backman JT, Alahuhta S, Seppänen T, Ala-Kokko T. Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury. Anesthesiology. 2017 Jan;126(1):94-103. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | EEG slow-wave activity | EEG slow-wave activity defined by the low-frequency (<1 Hz) signal power calculated continuously from the beginning of EEG measurement until 48 hours from cardiac arrest. The study investigates the association between the slow-wave activity and neurological outcome i.e. Cerebral Performance Category after 6 month follow-up period. | 0-48 hours |
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