Discover In-Hospital Cardiac Arrest

Cardiac Arrest Clinical Trial

— Discover IHCA  

Official title:

Discover In-Hospital Cardiac Arrest: A Prospective Multicenter Study of Post-In-Hospital Cardiac Arrest Management Practices

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06207201
• Other study ID #: 2022-14602
• Status: Recruiting
• Start date: October 16, 2023
• Est. completion date: August 2024

Study information

• Verified date: January 2024
• Source: Montefiore Medical Center
• Contact: Luke Andrea
• Phone: (718) 920-5731
• Email: landrea[@]montefiore.org
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The Discover In-Hospital Cardiac Arrest (IHCA) study is a multicenter, prospective observational study aimed at better understanding variations in practice for the post-in-hospital cardiac arrest patient.

Description:

There is considerable debate among experts concerning many components of intra- and post-arrest care. This study aims to increase the evidence base of these components, particularly temperature control, and prognostication in post-in-hospital cardiac arrest patients. In addition to providing insights regarding immediate and long-term post-arrest care, data collected will also be useful in studying variations in cardiopulmonary resuscitation practices. This project is endorsed by the Society of Critical Care Medicine's (SCCM) Discovery, the Critical Care Research Network.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 1000
• Est. completion date: August 2024
• Est. primary completion date: August 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult (=18 years old) patients
• Patients with a cardiac arrest (a lack of palpable pulse or perfusing cardiac activity) while admitted to the hospital
• Patients admitted to a ward (telemetry or non-telemetry) or an intensive care unit, or are admitted but still in the emergency department waiting for a hospital bed
• Patients who achieved return of spontaneous circulation (ROSC defined as >20 minutes of sustained spontaneous circulation) OR initiated on extracorporeal membrane oxygenation (eCPR) with chest compressions ongoing

Exclusion Criteria:

• Cardiac arrest in non-inpatients (e.g. outpatients, visitors)
• Patients whose cardiopulmonary resuscitation (CPR) starts outside of the hospital
• Non-index arrests (arrests that are not the patient's first arrest during the hospital admission; this also excludes patients who were initially admitted for an out-of-hospital cardiac arrest)
• Patients suffering IHCA in the operating room (OR) or post anesthesia care unit (PACU)
• Patients with cardiac arrest after arriving to an emergency department (ED) but prior to being evaluated and admitted to the hospital
• Cardiac arrests lasting <2 minutes (i.e. chest compressions performed <2 minutes)
• Cardiac arrests where the patient is transitioned to comfort focused care within 6 hours of return of spontaneous circulation (ROSC)

Related Conditions & MeSH terms

• Cardiac Arrest
• Heart Arrest

Locations

Country	Name	City	State
United States	Montefiore Medical Center	Bronx	New York

Sponsors (2)

Lead Sponsor	Collaborator
Montefiore Medical Center	Society of Critical Care Medicine

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fever Incidence	The incidence of fever from ROSC until 96 hours after ROSC among patients who remain comatose	Up to 96-hours post cardiac arrest
Primary	Multimodal Prognostication	The use of at least two approaches for prognostication prior to withdrawal of care from ROSC until hospital discharge	Up to 60 days post cardiac arrest
Primary	Early Withdrawal of Care	The withdrawal of care from ROSC until 72-hour after ROSC	Up to 72-hours post cardiac arrest