Thiamine as a Metabolic Resuscitator After Cardiac Arrest

Status Terminated

Clinical Trial Summary

Clinical Trial Description

This is a randomized, double-blind, placebo controlled study to investigate the effect of intravenous thiamine (vitamin B1) on lactate, cellular oxygen consumption, global oxygen consumption and biomarkers of neurologic injury after out-of-hospital cardiac arrest (OHCA). Patients who have sustained return of spontaneous circulation (ROSC) after OHCA and have a lactate of 3 or greater will be eligible for the study. Enrolled patients will be randomized to intravenous thiamine 500mg twice daily for 5 doses or matching placebo (100cc normal saline). Blood will be drawn at several time points and patients will be connected to a noninvasive monitor for continuous measurement of global oxygen consumption. The primary endpoint is change in lactate level. Secondary endpoints include change in pyruvate dehydrogenase activity, change in cellular and global oxygen consumption, change in NSE and S100 (biomarkers of neurologic injury) and CPC-E score (a score that assesses neurologic and functional impairment) at hospital discharge, 30 and 90 days. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03450707
Study type	Interventional
Source	Beth Israel Deaconess Medical Center
Contact
Status	Terminated
Phase	Phase 2
Start date	May 6, 2018
Completion date	February 19, 2022

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Thiamine as a Metabolic Resuscitator After Cardiac Arrest — THACA

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms