Cancer Clinical Trial
Official title:
Epigenetic and Genetic Effects in Cancer Patients: Analysis Pre and After Treatment
The prognosis in cancer patients has improved over the years. Survivor rates have increased
significantly, and paternity has become an important concern in more than 50% of young male
survivors. Sperm cryopreservation before cancer treatment is highly recommendable in these
patients, as a strategy to preserve their fertility due to is not possible to predict how the
chemo or radiotherapy treatment will affect the spermatogenesis.
The objective of this study is to evaluate if sperm after an antineoplastic treatment can be
safely used. To determine the possible effects of oncological treatments in the
spermatogenesis, three parameters will be analyzed, aneuploidy frequencies, DNA fragmentation
in single and double-strand breaks and methylation levels to determine epigenetic changes
before and after the therapy.
If cancer treatment affect sperm genetic integrity, it would have a clinical impact in the
offspring of these patients. Identify the different side effects of antineoplastic treatments
in DNA sperm will provide a clinical improvement in order to select the best sperm sample in
an IVF treatment and it will facilitate genetic counseling
n/a
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