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Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

Cancer Clinical Trial

Official title:
A Phase II Study of Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Clinical Trial Summary

This study will examine the combination of pembrolizumab and tadalafil for safety and efficacy in advanced head and neck cancer.

Clinical Trial Description

Immune competent animal models of HNSCC demonstrate that combination PDE-5 inhibitor (tadalafil) and PD-1 inhibitor therapy is more effective than either therapy alone based on the concept of targeting multiple immune repressive abnormalities simultaneously (PD-1 checkpoint and myeloid suppressive pathways). This trial will test the hypothesis that combination PD-1 inhibition and PDE-5 inhibition can be safely co-administered, and secondarily test the hypothesis that the combination of both therapies will be more effective than PD-1 inhibition alone in recurrent/metastatic HNSCC. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03993353
Study type Interventional
Source University of California, San Diego
Contact Khushbu Singh
Phone (858) 246-2604
Email ksingh@health.ucsd.edu
Status Recruiting
Phase Phase 2
Start date April 7, 2020
Completion date March 1, 2029
View Details
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