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NCT05834231 Clinical Trial

Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity

Cancer Clinical Trial

Official title:
Efficacy of Memantine in Prevention of Oxaliplatin-induced Peripheral Neurotoxicity

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05834231
Other study ID # 2023
Secondary ID
Status Not yet recruiting
Phase Phase 1/Phase 2
First received
Last updated
Start date August 2023
Est. completion date October 2024

Study information
Verified date April 2023
Source Mansoura University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Memantine is a drug for the management of Alzheimer's Disease (AD) due to its promising neuroprotective properties. We hypothesize that Memantine possesses a beneficial role against chemotherapy-induced neuronal damages.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 60
Est. completion date October 2024
Est. primary completion date March 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria: histologically confirmed diagnosis of stage III colorectal cancer performance status < 2 according to Eastern Cooperative Oncology Group (ECOG) score adequate renal function (glomerular filtration rate = 90) Exclusion Criteria: preexisting neuropathic or brain disorders, a previous use of chemotherapeutic agents including oxaliplatin use of drugs reported to have neuroprotective role

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Memantine
oral
• Placebo
oral

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Mansoura University

Outcome
Type Measure Description Time frame Safety issue
Primary Incidence of chemotherapy induced-peripheral neuropathy using National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) criteria 6 months
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