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Study of a PD-1 Inhibitor (JTX-4014) in Subjects With Solid Tumor Malignancies

Cancer Clinical Trial

Official title:
Phase 1 First in Human Study of Programmed Cell Death Receptor-1 (PD-1) Inhibitor Monoclonal Antibody (mAb) JTX-4014 in Adult Subjects With Advanced Refractory Solid Tumor Malignancies

Clinical Trial Summary

JTX-4014-101 is a Phase 1, open label, dose escalation clinical study of JTX-4014 in adult subjects with advanced refractory solid tumor malignancies, to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D).

Clinical Trial Description

JTX-4014 is a fully human IgG4 monoclonal antibody designed to specifically bind to PD-1 and block its interaction with its ligands, PD-L1 and PD-L2, to augment anti-tumor T cell activity. This is a Phase 1, first in human, open label, multicenter, dose escalation clinical study to evaluate the safety, tolerability, and PK of JTX-4014 when administered as a single agent to adult subjects with advanced refractory solid tumor malignancies. The intent of this study will be to determine the MTD and RP2D. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03790488
Study type Interventional
Source Jounce Therapeutics, Inc.
Contact
Status Completed
Phase Phase 1
Start date December 6, 2018
Completion date February 28, 2023
View Details
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