Cancer Clinical Trial
Official title:
A Feasibility Study of the Use of Actigraphy to Determine Prognosis in Patients With Advanced Cancer
This study evaluates the use of actigraphy-derived measures to improve prognostication in patients with advanced cancer.
An accurate assessment of prognosis (life expectancy) is important for cancer patients, their
carers, and their health care professionals. In the case of patients / their carers, it
allows them to plan for the future, and to make more informed decisions about further
anti-cancer treatments, and about referral to supportive and palliative care services.
However, previous research suggests that health care professionals are not particularly good
at estimating prognosis, and frequently over-estimate prognosis.
The aim of this project is to assess the usefulness of measuring physical activity, and
differences between daytime and nighttime physical activity, in determining prognosis in
patients with cancer. Studies suggest that these measures may be useful in determining
prognosis in certain groups of patients with cancer (e.g. patients receiving chemotherapy for
colon / rectum cancer). However, these studies need to be repeated in patients with different
types of cancer, and also patients receiving other types of treatment (including supportive
and palliative care). The aim of this small scale ("feasibility") study is to determine
whether or not a large scale ("definitive") study can be done.
The feasibility study will include 50 patients with cancer, who will be asked to rate their
performance status (physical activity) on a well-used scale, and then to wear a watch-like
device for one week that measures physical activity and sleep patterns. The researcher will
collect a blood sample: some of which will be used for analysis of parameters, which have
previously been identified as prognostic indicators and will collect and store some blood for
future transcriptome analysis. Participants will also be asked to complete a sleep diary
during the week, and a questionnaire about their symptoms at the beginning and end of the
week. The study will last one week in total and is collaboration between the Royal Surrey
County Hospital, and the University of Surrey (Surrey Sleep Research Centre).
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