Plant-based Diets and Risk of Cancer in the Adventist Health Study-2

Cancer, Breast Clinical Trial

— AHS-2  

Official title:

Cancer Epidemiology in Seventh-day Adventists

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03615599
• Other study ID #: 48134
• Secondary ID: U01CA152939R01CA
• Status: Active, not recruiting
• Start date: February 1, 2002
• Est. completion date: December 2024

Study information

• Verified date: November 2023
• Source: Loma Linda University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The Adventist Health Study-2 is a long-term study, exploring the links between lifestyle, diet, and disease outcomes among Seventh-day Adventists. More than 96,000 church members from the U.S. and Canada are participating in the current study, AHS-2, conducted by researchers at the Loma Linda University School of Public Health.

Description:

The Adventist Health Study-2 (AHS-2) is a large national cohort of 96,000 Seventh-day Adventists in the U.S. and Canada. The study is searching for associations between diet and risk of common and medium frequency cancers (breast, prostate, colorectal, lung, uterus, pancreas, melanoma of skin). This cohort is unusual in that about half are vegetarian, many eat soy at Asian levels, and many have very low or absent dairy intake while others eat normal amounts of dairy. Thus observations on these people, many of whom have contrasting dietary habits, may provide insights about diet and cancer, so supporting dietary changes that could be readily adopted by many.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 96000
• Est. completion date: December 2024
• Est. primary completion date: December 31, 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years and older

Eligibility

Inclusion Criteria:

• Member of a Seventh-day Adventist church >30 years of age Ability to read English Live in the US or Canada

Exclusion Criteria:

• Less than 30 years of age

• Church members who did not complete the baseline questionnaire.

• Incarcerated or institutionalized people

• Non-English speakers

Related Conditions & MeSH terms

• Breast Neoplasms
• Cancer, Breast
• Cancer, Colorectal
• Cancer, Prostate
• Colorectal Neoplasms
• Prostatic Neoplasms

Locations

Country	Name	City	State
United States	Loma Linda University	Loma Linda	California

Sponsors (4)

Lead Sponsor	Collaborator
Loma Linda University	Ardmore Institute of Health, National Cancer Institute (NCI), World Cancer Research Fund International

Country where clinical trial is conducted

United States, 

References & Publications (1)

Butler TL, Fraser GE, Beeson WL, Knutsen SF, Herring RP, Chan J, Sabate J, Montgomery S, Haddad E, Preston-Martin S, Bennett H, Jaceldo-Siegl K. Cohort profile: The Adventist Health Study-2 (AHS-2). Int J Epidemiol. 2008 Apr;37(2):260-5. doi: 10.1093/ije/dym165. Epub 2007 Aug 27. No abstract available. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Incident cases of colorectal cancer among subjects with documented dietary habits.	Incident cases of colorectal cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.	Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.
Primary	Incident cases of breast cancer among subjects with documented dietary habits.	Incident cases of breast cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.	Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.
Secondary	Incident cases of prostate cancer among subjects with documented dietary intakes.	Incident cases of prostate cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.	Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.