Serum Opiorphin Level After Intraoperative Intravenous Lidocaine Infusion

Cancer, Breast Clinical Trial

Official title: Serum Opiorphin Level After Intraoperative Intravenous Lidocaine Infusion and Its Relation to Post-mastectomy Pain: a Prospective Double Blinded Study

Status Completed

Clinical Trial Summary

A prospective, double blinded and randomized study included women with breast cancer and underwent mastectomy, and randomly allocated into two groups of equal size. Lidocaine group and control group.

Clinical Trial Description

Women aged between 18 and 60 years old with breast cancer and underwent mastectomy, ASA I or II were included in the study.

• Group I (lidocaine): Patients were received intravenous 1 mg/kg of 2 % lidocaine as a loading dose (just before induction of anesthesia) then received 2mg/kg /h lidocaine as maintenance dose (with maximum of 200 mg/h) till the end of the operation (skin closure).

• Group II (control):- A standardized equal volume of intravenous bolus dose of normal saline was given as loading dose then normal saline was administered on an equal rate of infusion. ;

Related Conditions & MeSH terms

• Breast Neoplasms
• Cancer, Breast

• NCT number: NCT03502395
• Study type: Interventional
• Source: Assiut University
• Status: Completed
• Phase: Phase 1
• Start date: April 4, 2017
• Completion date: February 13, 2018