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Burn Injury clinical trials

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NCT ID: NCT06263296 Recruiting - Quality of Life Clinical Trials

Smartphone Assisted Self-management Education for Adult Burn Patient at Aftercare

Start date: May 27, 2024
Phase: N/A
Study type: Interventional

Burn rehabilitation management is dependent on the patients themselves, non-treatment adherence may delay the optimal timing of burn rehabilitation and it may not be regained easily. The inevitable sequelae of increasing joint stiffness and tethered soft-tissue glide become more devastating over time. It has a major impact on clinical outcomes such as scarring, deformity and dysfunction, which result in lower quality of life compared to general population There is a growing body of research on patient-centered interventions including the concept of self-management. Such phenomenon is consistent with burn patients' needs at aftercare. The proposed smartphone self-management program is to change the paradigm from paternalistic to collaborative relationship. Self-management is to build up patient equipping ability in problem solving, decision making, and appropriate use of resources and has led to improved patient engagement, adherence, and better quality of care. The investigators hypothesize that, upon intervention completion and compared with the control group, burn patients in the intervention group will report: 1. Higher level of health-related quality of life, 2. Higher level of self-efficacy 3. Higher level of score in Burn Rehabilitation Knowledge 4. Lower pain level, as measured by Numeric Pain Rating Scale; and 5. Lower level of itchiness The desired smart phone assisted self-management intervention will be carried out by principal investigator to selected adult burn patients before discharge and post discharge period. Before discharge, ward nurses will provide discharge pamphlet and individual face to face education to both groups as usual care. After discharge, instant messaging supportive enquiry service will be provided to both groups via smartphone apps. For intervention group, principal investigator will assess subject health care needs prior to intervention. Two extra sessions, 20 minutes, face to face, individual self-management education with aid of computer, track log sheet will be provided to intervention group. Concept of motivational interviewing will be incorporated as complement teaching strategy to facilitate self-management learning. Principal investigator will be responsible to deliver burn self-management education upon discharge. Intervention group will receive "Rehabilitation Booklet for Burn Patients" upon discharge. After discharge, only intervention group subject receives two sessions, 10 minutes, telephone follow up calls and five personalized chat-based messaging follow up will be provided. Besides that, self-management education information will be delivered to intervention group via instant messaging service as well. Ad-hoc instant messaging support will be provided to both groups if required.

NCT ID: NCT05876442 Recruiting - Burn Injury Clinical Trials

Efficacy of EPSW Plus HILT on Carpal Tunnel Syndrome Post Burn Injury

Start date: May 20, 2023
Phase: N/A
Study type: Interventional

To study the effect of adding ESWT as a noninvasive short-term treatment plus high-level laser therapy for moderate carpal-tunnel syndrome post-burn injuries.

NCT ID: NCT05856994 Recruiting - Burn Injury Clinical Trials

Clinical Assessment of Protopic® Ointment in Deep Partial-Thickness Burns

Start date: August 1, 2023
Phase: Phase 1
Study type: Interventional

There is currently no standard treatment to prevent burn depth conversion in partial-thickness burns. Conversion into deeper wounds is associated with higher complications and morbidity. The most common theory attributes this depth conversion to the prolonged inflammatory response that occurs after burn injury. Therefore, the investigators propose testing the safety and efficacy of tacrolimus ointment (an immunosuppressive agent) in patients with deep partial-thickness burns.

NCT ID: NCT05619289 Recruiting - Chronic Pain Clinical Trials

Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn

Start date: April 12, 2023
Phase: Phase 2
Study type: Interventional

The goal of this pilot clinical trial is to learn whether vitamin D is able to prevent chronic pain following burn injury and to determine what biological mechanisms are engaged by Vitamin D following burn injury. The main question[s] it aims to answer are: - Is the clinical trial protocol feasible? - Is Vitamin D administration following burn injury safe? - How does vitamin D cause changes in the immune system in the aftermath of burn injury? Following informed consent, participants will be asked to: - Take 6 capsules by mouth one time following burn injury (Vitamin D or Placebo) - Provide a blood sample at baseline and 6 weeks following injury - Fill out surveys daily while in the hospital, weekly through 6 weeks, and at 3 months and 6 months. Researchers will compare Vitamin D and placebo groups to see if there are differences in adverse effects (side effects), chronic pain, and profiles of immune cells from collected blood samples.

NCT ID: NCT04947449 Recruiting - Burn Injury Clinical Trials

Potential Benefits of Laser Treatment on Skin Blood Flow and Sweating in Burn Survivors

Start date: July 29, 2021
Phase:
Study type: Observational

The purpose of this study is to examine effects of laser therapy on blood flow and sweating responses in burn-injured skin.

NCT ID: NCT04368117 Recruiting - Burn Injury Clinical Trials

STAT: Standard Therapy Plus Active Therapy

STAT
Start date: October 26, 2020
Phase: N/A
Study type: Interventional

The objective of the study is to assess the efficacy of STAT, an activity-based therapy protocol compared to standard therapy (ST) to improve functional outcome and reduce disability in patients recovering from burn injury. This randomized multi-center trial is designed with two parallel treatment groups: STAT and ST. Efficacy of the STAT protocol will be determined through comparison to the ST only group. It will be conducted at seven burn centers.

NCT ID: NCT04356859 Recruiting - Burn Injury Clinical Trials

The Acute Burn ResUscitation Multicenter Prospective Trial

ABRUPT2
Start date: April 22, 2021
Phase: N/A
Study type: Interventional

This is a prospective randomized multi-center study which will compare acute fluid resuscitation using a colloid strategy (LR + 5% Albumin) to a crystalloid strategy (LR alone), in adults with an acute burn involving at least 25% of their total body surface area.

NCT ID: NCT03618940 Recruiting - Burn Injury Clinical Trials

Module on Preventing Fire, Burns and Scalds Injury Among Children

Start date: January 1, 2016
Phase: N/A
Study type: Interventional

The main aim of this intervention study is to test the hypothesis if school based educational intervention program will significantly improve the knowledge of primary school student on childhood burn prevention in Kuala Lumpur. The secondary aim the evaluate the association of demographics background, burn injury history with knowledge on burn. The study was conducted in 12 primary school in Kuala Lumpur from 1st January 2015 to 31st December 2017 in three different phases.

NCT ID: NCT02251626 Recruiting - Burn Injury Clinical Trials

Assessing Bioavailability of CoQ10 Supplementation in Burn Patients

CoQ10
Start date: April 2014
Phase: Phase 0
Study type: Interventional

To test the hypotheses that plasma and intracellular coenzyme Q10 levels will decline after burn injury and that ubiquinol supplementation will increase plasma and intracellular coenzyme Q10 levels in burn patients. To test the hypothesis that ubiquinol supplementation ameliorates mitochondrial dysfunction/disintegrity and metabolic derangements, and decreases circulating alarmins (a.k.a. endogenous DAMPs) in burn patients as compared with placebo.

NCT ID: NCT02189538 Recruiting - Burn Injury Clinical Trials

Effect of n-3 PUFA From Fish in Enteral Nutrition of Major Burn Patients

OmegaBurn
Start date: January 2013
Phase: N/A
Study type: Interventional

Studies have shown that burn patients may benefit from low fat diets, but there is still no strong data regarding the impact of fatty acid composition used for feeding. The trial test the hypothesis that the inclusion of omega-3 PUFA in a low fat diet may improve outcome. Prospective randomised controlled trial in adult patients admitted for burns > 15% body surface area (BSA), and inhalation injury requiring mechanical ventilation and enteral nutrition. On admission randomization to receive a low-fat (18% energy as fat) modular enteral diet (LF-EN) and identical with the half of fat provided by fish oil (FO-EN). Study endpoints: mechanical ventilation time, inflammation (CRP), infectious and other complications, mortality until discharge. The study is planed as 2 parts: 1) preliminary study testing the feasibility of the study, 2) the study completed with information from the preliminary phase, both phases being randomised and controlled.