Clinical Trials Logo

Clinical Trial Summary

In this study, we will study 129Xe-MRI and LCI as tools for diagnosis of BOS in pediatric patients who have received Hematopoietic Stem Cell Transplantation (HSCT) and have been identified as eligible for this study. Participants will be required to have vital signs collected, complete breathing tests and complete an MRI. The MRI will require participants to perform breath holds in the MRI scanner with xenon gas while being coached by a research assistant.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04391335
Study type Observational
Source The Hospital for Sick Children
Contact Giles Santyr
Phone 4168137654
Email giles.santyr@sickkids.ca
Status Recruiting
Phase
Start date October 20, 2020
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Completed NCT01807975 - Forced Oscillation Versus Spirometry in Diagnosing Post Pulmonary Transplant Bronchiolitis Obliterans Syndrome N/A
Completed NCT01009619 - Azithromycin in Bronchiolitis Obliterans Syndrome Phase 4
Recruiting NCT05250037 - The Longitudinal Impact of Respiratory Viruses on Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Cell Transplantation (The RV-BOS Study)
Enrolling by invitation NCT04039347 - Extension Trial on Efficacy / Safety of L-CsA + SoC in Treating BOS in Post Single or Double Lung Transplant (BOSTON-3) Phase 3
Recruiting NCT05413356 - Ruxolitinib for Newly Diagnosed Bronchiolitis Obliterans Syndrome Phase 2
Recruiting NCT00774449 - Characterization of Bronchiolitis-obliterans Syndrome (BOS) Following Lung Transplantation N/A
Recruiting NCT05922761 - BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP) Phase 2
Terminated NCT03978637 - Safety and Efficacy of Itacitinib in Participants With Bronchiolitis Obliterans Syndrome Following Lung Transplantation Phase 1/Phase 2
Completed NCT02316392 - Imaging and Understanding BOS in Lung Transplantation
Completed NCT00528853 - Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation N/A
Recruiting NCT06018766 - LAM-001 in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome. Phase 2
Recruiting NCT02669251 - Alvelestat (MPH966), an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation Phase 1/Phase 2
Completed NCT02863835 - Evaluation of Electrical Impedance Tomography for the Diagnosis of Chronic Rejection in Lung Transplants Recipients N/A
Recruiting NCT03072849 - Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation N/A