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Clinical Trial Summary

This is a first-in-human, open label, multicenter study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and the preliminary antitumor activity of TAS2940 in patients with advanced or metastatic solid tumors who are not candidates for approved or available therapies.


Clinical Trial Description

TAS2940 is a small molecule inhibitor of ERBB family proteins HER2 and EGFR. It has not been evaluated in human subjects yet. The study will be conducted in 2 parts, dose escalation and dose expansion. The dose escalation part will assess the safety and determine the maximum tolerated dose, the recommended phase 2 dose and the recommended dosing regimen of TAS2940 administered orally. The dose expansion part will assess preliminary anti-tumor activity in select solid tumors characterized by HER2 or EGFR aberrations. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04982926
Study type Interventional
Source Taiho Oncology, Inc.
Contact Taiho Oncology, INC
Phone 609-250-7336
Email clinicaltrialinfo@taihooncology.com
Status Recruiting
Phase Phase 1
Start date September 16, 2021
Completion date June 2025

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