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Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors

Breast Cancer Clinical Trial

Official title:
Phase 1/2 Dose Escalation, Safety, Pharmacokinetics, and Efficacy Study of NUV-422 in Adults With Recurrent or Refractory High-grade Gliomas and Solid Tumors

Clinical Trial Summary

At the time of study termination, NUV-422-02 was a first-in-human, open-label, Phase 1 dose escalation study designed to evaluate the safety and efficacy of NUV-422. The study population comprised adults with recurrent or refractory high-grade gliomas (HGGs), metastatic breast cancer (mBC), with and without brain metastases, and recurrent or refractory metastatic castration-resistant prostate cancer (mCRPC). All patients self-administered NUV-422 orally in 28-day cycles until disease progression, toxicity, withdrawal of consent, or termination of the study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

  • Advanced Breast Cancer
  • Advanced Breast Carcinoma
  • Breast Cancer
  • Breast Carcinoma
  • Breast Neoplasms
  • Breast Tumor
  • Cancer of Breast
  • Cancer of Prostate
  • Cancer of the Breast
  • Cancer of the Prostate
  • Carcinoma
  • Castrate Resistant Prostate Cancer
  • Castration Resistant Prostatic Neoplasms
  • Castration-resistant Prostate Cancer
  • Glial Cell Tumors
  • Glioblastoma
  • Glioma
  • Glioma, Malignant
  • Glioma, Mixed
  • Malignant Tumor of Breast
  • Metastatic Breast Cancer
  • Metastatic Breast Carcinoma
  • Neoplasms
  • Prostate Cancer
  • Prostate Neoplasm
  • Prostatic Cancer
  • Prostatic Neoplasms
  • Prostatic Neoplasms, Castration-Resistant
  • Recurrence
  • Recurrent Glioblastoma
Clinical Trial Details
NCT number NCT04541225
Study type Interventional
Source Nuvation Bio Inc.
Contact
Status Terminated
Phase Phase 1
Start date December 8, 2020
Completion date August 31, 2022
View Details
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