Dose Escalation Study to Assess the Safety, Tolerability,

Status Completed

Clinical Trial Summary

This is a multi-center, open-label, dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of QBS10072S in patients with advanced or metastatic cancers with high LAT1 expression. The MTD of QBS10072S will be confirmed in patients with relapsed or refractory grade 4 astrocytoma.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Astrocytoma
Bladder Cancer
Brain Cancer
Brain Metastases
Brain Neoplasms
Breast Cancer
Cervical Cancer
Cholangiocarcinoma
Colorectal Cancer
Esophageal Neoplasms
Esophagus Cancer
Gastric Cancer
Head and Neck Cancer
Kidney Cancer
Liver Cancer
Lung Cancer
Melanoma
Mesothelioma
Neoplasm Metastasis
Ovarian Cancer
Pancreatic Cancer
Pleural Mesothelioma
Prostate Cancer
Sarcoma
Thymic Carcinoma
Thymoma
Tongue Cancer
Tongue Neoplasms
Urinary Tract Cancer
Urologic Neoplasms

Clinical Trial Details

NCT number	NCT04430842
Study type	Interventional
Source	Quadriga Biosciences, Inc.
Contact
Status	Completed
Phase	Phase 1
Start date	July 20, 2020
Completion date	December 22, 2022

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Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms