Breast Cancer Clinical Trial
Official title:
TIVA Versus Volatile Anesthetics Admnistration on Stress and Pain Levels During Autologous Fat Transfer in Breast Reconstruction, in a Day Care Center
The aim of the present study is to investigate the effect of intravenous anesthetics versus the administration of volatile anesthetics on stress and pain levels during autologous fat transfer for breast reconstruction in a Day Care Center.
The sample of the study will be patients who will have Autologous Fat Transfer for Breast
Reconstruction.
Patients will be divided into 2 groups. The TIVA group (N = 23) will be administrated
intravenous anesthesia (propofol-remifentanil), while the DES group (N = 23) volatile
anesthetics (desflurane-remifentanil).
Specifically, the TIVA group will include patients over 50 years of age with high risk of
nausea / vomiting and postoperative delirium, as well as suspicion of malignant hyperthermia.
Patients with cardiac and respiratory problems will be included in the DES group.
The following data will be collected in the Data Sheet: Patient Demographics (Gender, Age),
Body Mass Index (Body Height- Body Weight). Simultaneously, the pain levels will be evaluated
by VAS Optical Analogue Scale of VAS 0-10 in PACU, preoperatively and postoperatively, and
perioperative pain levels will be assessed with CPOT scale (values 0-8).
Stress levels will be evaluated with 3 NAS questions: a. How sad do you feel right now? b.
How anxious do you feel right now? and c. How optimistic do you feel right now?. The 3 NAS
questions will also be given preoperatively and postoperatively to the ward. The sedation
levels will be assessed by RASS scale (values +4 to -5) and the Bispectral Index (BIS). The
level of patient's awareness will be assessed by GCS Scale (3 (indicating deep
unconsciousness) and either 14 (original scale) or 15 (more widely used modified or revised
scale)).
The presence or absence of nausea / vomiting and the appearance of immediate postoperative
complications will be examined. Finally, post-operative stress will be examined with stress
biomarkers, salivary ACTH hormone and salivary cortisol hormone.
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