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RNA and Heat Shock Protein Biomarkers in Radiation-induced Fibrosis in Breast Cancer — SPLICI-Rad  

Breast Carcinoma Clinical Trial

Official title:
Study of RNA and Heat Shock Protein (HSP) Derived Biomarkers in Radiation-induced Fibrosis in Patients Treated for Breast Cancer.

Clinical Trial Summary

The purpose of this study is to seeking a molecular signature of pathological radiation induced fibrosis based on the response of skin fibroblasts after irradiation, comparing two groups of patients distinguished by their individual radiosensitivity. The signature will integrate recent insights in terms of alternative splicing of mRNAs and level of expression of non-coding RNAs, particularly long non-coding RNAs, snRNAs, snoRNAs and microRNAs. In each group each expression patterns of candidate HSP proteins potentially predictive of pathological radiation induced fibrosis (HSP27, HSP70, αβ crystalline) in the serum and on cell culture will be characterized.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03000764
Study type Interventional
Source Institut de Cancérologie de Lorraine
Contact
Status Completed
Phase N/A
Start date May 10, 2017
Completion date April 25, 2018
View Details
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