Breast Cancer Clinical Trial
Official title:
A Phase II Study of Cabazitaxel for Patients With Breast or Lung Cancer and Recurrent or Progressive Brain Metastases - Cabazitaxel for Brain Metastases (CaBaMet)
Patients suffering from histologically or cytologically confirmed stage IV lung or breast cancer with progressive or recurrent brain metastases after prior external beam radiotherapy will receive treatment with cabazitaxel until progression of brain metastases (BM) or unacceptable toxicity.
Cabazitaxel is a new taxane compound that exhibited a broad spectrum of in vivo antitumor
activity, not only in docetaxel - sensitive tumor models, but also in tumors models in which
docetaxel was poorly or not active. In contrast to other taxanes, cabazitaxel has the ability
to cross the blood-brain-barrier. Marked antitumor activity was obtained in nude mice bearing
intracranial glioblastomas. Consequently, there is a good rationale to investigate
cabazitaxel in patients with breast or lung cancer and recurrent or progressive brain
metastases.
The primary object of the study is to measure objective tumor response of brain metastases
for patients with breast or lung cancer and recurrent or progressive brain metastases.
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