Breast Cancer Clinical Trial
Official title:
Amino Acid Transport Imaging of Breast Carcinoma Via Anti-3-[18F]FACBC PET-CT: A Pilot Study
Breast carcinoma is the most frequent cancer in women, affecting an estimated 207,090 in
2010 leading to 39,840 cancer related deaths.
Fludeoxyglucose F 18 Injection (FDG) Positron Emission Tomography, (PET) or PET-CT has
become the a standard method for isolating the tumor. However, FDG is insensitive in small
breast tumors and certain histologic types such as lobular, certain types of breast
carcinoma. In addition, FDG uptake can be nonspecific since inflammatory some benign lesions
may also evidence have accumulation of this radiotracer. Hence there is a need for a
tracer/imaging tool that increases the ability to characterize detect breast carcinoma and
to detect locoregional spread, as well as monitor therapeutic treatment response.
anti-3-[18F]. anti-1-amino-3-[18F]fluorocyclobutyl-1-carboxylic acid (FACBC) is an amino
acid based PET radiotracer which has shown utility in detecting a variety of tumors. In cell
culture experiments,FACBC has shown uptake in the breast tumor cell line.
The primary aim of this study is to determine if FACBC PET-CT demonstrates uptake within
breast carcinoma (primary site and/or locoregional lymph nodes) and to study uptake kinetics
via time-activity curves from dynamic imaging characteristics. The investigators will enroll
12 patients who have a breast mass or masses and/or lymph nodes naïve to therapy about to
undergo biopsy or post-biopsy pre-therapy. All patients will undergo standard of care
imaging as appropriate such as mammography, ultrasound, MR, and/or FDG PET-CT scanning. The
investigators will then compare findings to determine if this radiotracer is worthy of
further study in a more comprehensive experiment.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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