Breast Cancer Clinical Trial
The purpose of this study is to evaluate the use of advanced quantitative mass spectometry
(Super SILAC) as a discovery platform to uncover novel protein biomarkers in tumor and to
compare the protein profile between different subtypes of breast cancer (ER positive, HER2
positive, triple negative). A maximum of 100 breast tumor specimens will be obtained from
the NUHS Tissue repository, comprising approximately equal proportion of ER positive, HER2
positive, and triple negative tumors. Samples will be analyzed using advanced Mass
Spectrometry (Super SILAC) as a discovery platform to identify novel protein biomarkers that
may be important in cancer. DNA and RNA will also be extracted from tumor samples for
correlative analysis with the proteomics data. Genomics and proteomics data will be
correlated with clinical data including treatment response and survival data. Importance of
proposed research to science or medicine:Identification of tumor biomarkers may allow better
prognostication, follow-up, and selection of treatment for cancer patients in the future.
Potential benefits and risks: No direct benefit to the patient. Risk to the subjects is
minimal as there is no direct patient contact, and analysis is done on previously donated
tumor samples. Patients have previously provided consent to donate their samples for
research into the NUHS Tissue Repository.
Novel tumor biomarkers that determine tumor biology, including prognosis and treatment
sensitivity, may be detectable using the novel advanced quantitative mass spectromy method
(Super SILAC). Different subtypes of breast cancers will have different proteomic profiles
analyzed using super SILAC.
n/a
Observational Model: Cohort, Time Perspective: Retrospective
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