Breast Cancer Clinical Trial
Official title:
Probiotic Enteric Regimen For Easing Complications of Transplant : A Pilot Study (PERFECT Trial)
RATIONALE: Probiotics, such as Lactobacillus, may be effective in preventing infections in
patients with suppressed immune systems.
PURPOSE: This phase I trial is studying the side effects and how well giving enteral
nutrition, including Lactobacillus, works in preventing infections in patients undergoing
donor stem cell transplant for hematologic cancer or myelodysplastic syndrome.
OBJECTIVES:
- To determine if patients who are treated with a probiotic-containing diet develop
infection with one of the probiotic microorganisms while undergoing allogenic
hematopoietic stem cell transplantation for a hematologic malignancy or myelodysplastic
syndrome.
OUTLINE: Patients receive oral Lactobacillus rhamosus GG (Culturelle DS) once daily
beginning when blood counts have recovered without filgrastim (G-CSF) or sargramostim
(GM-CSF) support for 3 consecutive days and continuing for 1 year after transplantation.
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