Breast Cancer Clinical Trial
Official title:
Open-Label Single-Arm Pilot Study of Deferasirox (Exjade®) in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload
RATIONALE: Deferasirox may be effective in treating iron overload caused by blood
transfusions in patients who have undergone donor stem cell transplant.
PURPOSE: This phase II trial is studying the side effects and how well deferasirox works in
treating patients with iron overload after donor stem cell transplant.
OBJECTIVES:
Primary
- To evaluate the safety of deferasirox given over 6 months in reducing liver iron
concentration in patients with transfusional iron overload after undergoing allogeneic
hematopoietic stem cell transplantation.
Secondary
- To evaluate the efficacy of deferasirox in reducing liver iron overload in these
patients.
OUTLINE: This is a multicenter study.
Patients receive oral deferasirox once daily for 6 months in the absence of disease
progression or unacceptable toxicity.
After completion of study therapy, patients are followed at 4 weeks.
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