Breast Cancer Clinical Trial
Official title:
Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment, A Pilot Study
The investigators hypothesize that continuous active interaction with environments that are demanding to sensory, cognitive, and motor systems, together with imbedded rewards for successful performance, will help improve memory and cognitive functioning in patients suffering from "chemobrain".
Breast cancer is the most common malignancy in women in the United States, with an estimated
211,240 new cases of invasive breast cancer diagnosed among women, and 1,700 diagnosed in
men, in 2005. While cure rates have improved significantly, chemotherapy for breast cancer
is associated with a number of negative side effects. One of which is a deficit in cognitive
function, a condition commonly referred to as "chemobrain". While the debate about cognitive
decline being a result of chemotherapy is still ongoing, there is clear evidence of
cognitive decline in women with breast cancer post-chemotherapy. Cognitive decline is often
reported to affect memory, attention, executive functioning and information processing
speed.
Studies suggest that incidence of "chemobrain" ranges from 17% - 75% in women who have
undergone chemotherapy.This cognitive impairment affects quality of life by impacting
patients' ability to concentrate, make decisions and to fulfill family, career, and
community responsibilities.
Although there is uncertainty about the mechanisms that can lead to this cognitive decline,
there is a pressing need to identify interventions that will alleviate its symptoms and help
breast cancer survivors recover their cognitive functioning and resume their roles and
activities at the pre-cancer level.
Brain plasticity refers to the brain's capacity for physical and functional change; it is
this capacity that explains how experience induces learning throughout life. On the basis of
a growing body of literature in the fields of psychophysics, neurology, neuropsychology, and
brain plasticity, we hypothesize that the brain processing machinery can be refined,
elaborated, and strengthened through rigorous training and learning. The purpose of this
study is to investigate if such training can improve cognitive functioning.
We hypothesize that continuous active interaction with environments that are demanding to
sensory, cognitive, and motor systems, together with imbedded rewards for successful
performance will help improve memory and cognitive functioning in patients suffering from
"chemobrain".
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Supportive Care
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