Brain Metastasis Clinical Trial
Official title:
Effectiveness and Safety of Whole-brain Radiotherapy With/Without TMZ Concurrent Chemotherapy or Avoidance of Hippocampus for Patients of Brain Metastases: a Multi-institutional, Randomized Controlled Clinical Trial
The purpose of this study is to evaluate the effects on neurocognitive function of whole-brain radiotherapy (WBRT) with/without TMZ concurrent chemotherapy or avoidance of hippocampus for patients of brain metastases, as well as the feasibility and risk of avoidance of hippocampus during whole-brain radiotherapy.
This is a phase II randomized clinical trial. It is reported that avoidance of hippocampus
during whole-brain radiotherapy (WBRT) had benefits in preservation of memory for patients,
and the use of concurrent TMZ in radiotherapy for patients with brain metastases benefited
for treating outcome.
The purpose of this study is to evaluate the effects on neurocognitive function of
whole-brain radiotherapy with/without TMZ concurrent chemotherapy or avoidance of
hippocampus for patients of brain metastases, as well as the feasibility and risk of
avoidance of hippocampus during whole-brain radiotherapy.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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