Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to determine whether the use of Trental and Vitamin E can help reduce the incidence of radiation necrosis (a lesion that usually occurs at the original tumor site) after radiosurgery. These two drugs are commonly used to treat radiation necrosis when it occurs but the hope is that these drugs can be used to prevent radiation necrosis from ever occurring.


Clinical Trial Description

The treatment phase of the study is 6 months. Study procedures will be conducted such as: history, physical and neurological exam, pregnancy testing (for women of child bearing age) and a Brain MRI. Follow-up appointments will be every 3 months for 1 year at which time, your participation in the study will be concluded. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01508221
Study type Interventional
Source University of Cincinnati
Contact
Status Completed
Phase Phase 2
Start date June 2011
Completion date February 1, 2017

See also
  Status Clinical Trial Phase
Withdrawn NCT01913067 - Evaluation of Cabazitaxel in Patients With Brain Metastasis Secondary to Breast Cancer and NSCLC Phase 2
Completed NCT02662725 - Ipilimumab Combined With a Stereotactic Radiosurgery in Melanoma Patients With Brain Metastases Phase 2
Completed NCT00406835 - Prospective Randomized Trial Between WBRT Plus SRS Versus SRS Alone for 1-4 Brain Metastases Phase 3
Completed NCT01724801 - Icotinib or Whole Brain Irradiation in EGFR-mutant Lung Cancer Phase 3
Completed NCT00219297 - Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer Phase 2
Withdrawn NCT02328300 - FLT PET/MR for Evaluation of Pseudoprogression in Patients With Brain Lesions
Terminated NCT01324635 - Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors Phase 1
Terminated NCT01894633 - Study of Whole-brain Irradiation With Chloroquine for Brain Metastases Phase 2
Recruiting NCT02681549 - Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer Phase 2
Terminated NCT02279992 - Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases Early Phase 1
Completed NCT02913534 - Hypofractionated Stereotactic Radiation Therapy of Brain Metastases: Evaluation of Whole-brain Radiotherapy N/A
Completed NCT01942980 - Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer Phase 3
Terminated NCT01363557 - Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis N/A
Active, not recruiting NCT05102747 - Stereotactic Radiotherapy in Oligometastatic Brain Disease: a Randomised Phase III Study Comparing Hypofractionated Stereotactic Radiation Therapy (3*10 Gy) to the Historical Single-dose Radiosurgery (1*20 to 25 Gy) With Medico-economic Evaluation. N/A
Recruiting NCT01891708 - VEGFRs Predict Bevacizumab Benefit in Advanced Non Small Cell Lung Cancer N/A
Completed NCT00587964 - Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases Phase 2
Not yet recruiting NCT02832635 - A Clinical Trial on Whole-brain Radiotherapy With Temozolomide Concurrent Chemotherapy or Avoidance of Hippocampus for Patients of Brain Metastases Phase 2
Completed NCT01395407 - Phase I Trial of Stereotactic Radiosurgery Following Surgical Resection of Brain Metastases Phase 1
Terminated NCT02433171 - Methionine and PBR28-PET (Peripheral Benzodiazepine Receptors) in Brain Metastases Following Radiosurgery
Recruiting NCT02504788 - A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive Function Decline N/A