Evaluation of CTA on the Assessment of Brain Death

Status Recruiting

Clinical Trial Summary

At present, different countries have different standards for the diagnosis of brain death, but according to the classic brain death confirmation test, it needs to be combined with transcranial Doppler, EEG, evoked potential and apnea test in clinical practice. Some patients cannot undergo a complete clinical examination and apnea test due to certain factors, and the determination of brain death is limited. The American Academy of Neurology (AAN) guidelines regard cerebral angiography as an acceptable auxiliary examination and is widely regarded as the gold standard for cerebral blood flow evaluation. CT cerebrovascular angiography (CTA) is a noninvasive and widely used examination method that can identify missing or severely reduced cerebral blood flow. However, due to limited experience and lack of sufficient evidence to prove its reliability, it is not included in the AAN A recognized auxiliary examination; there are also a large number of domestic and foreign literature reports that CTA can be used as a new confirmation test for clinical judgment of brain death. This study aims to explore the value of CTA in the judgment of patients with brain death.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04914039
Study type	Observational [Patient Registry]
Source	Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact
Status	Recruiting
Phase
Start date	February 1, 2021
Completion date	February 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03765814` - The Anticipated Organ Donation Approach
Completed	`NCT02581111` - Naloxone for Optimizing Hypoxemia Of Lung Donors	Phase 2/Phase 3
Completed	`NCT00808691` - Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit	N/A
Completed	`NCT00998972` - N-acetyl-cysteine (NAC) and Kidney Graft Function	Phase 3
Completed	`NCT04528797` - Thyroid and Adrenocortical Hormone Replacement in Organ Donors	N/A
Completed	`NCT03672812` - The Use of Liraglutide in Brain Death	Phase 3
Completed	`NCT04303624` - Understanding Family Refusal
Completed	`NCT03098706` - Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function	N/A
Not yet recruiting	`NCT04623294` - Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared Spectroscopy
Recruiting	`NCT02102945` - Special Imaging Technique to Aid in the Diagnosis of Patients in Coma After Cardiac Arrest	N/A
Completed	`NCT02483273` - Alterations of Conjunctival Microcirculation in Brain Dead Patients	N/A
Terminated	`NCT00675272` - Organ Donation and Hydrocortisone Treatment	N/A
Completed	`NCT03262896` - Neurophysiological Examination in Patients With Brain Death
Not yet recruiting	`NCT06359119` - Implementation of Apnoea Test for Patients With Suspected Brain Death
Recruiting	`NCT05202886` - "LiverColor": Machine Learning in Liver Photographs	N/A
Completed	`NCT03281993` - Apnea Tests as the Methods of Brain Death Diagnosis.	N/A
Completed	`NCT03179020` - Donation Network to Optimize Organ Recovery Study	N/A
Completed	`NCT05070182` - Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)
Terminated	`NCT03439995` - Goal of Open Lung Ventilation in Donors	N/A
Completed	`NCT02525510` - Deceased Organ Donor Interventions to Protect Kidney Graft Function	N/A