Clinical Trials Logo

Clinical Trial Summary

There is evidence of the association of brain death and inflammation, affecting outcomes of transplanted organs, but in a way not fully understood. Observational studies suggest that the use of target-guided therapies has a beneficial effect in reducing the rate of donor loss due to cardiac arrest and increasing the rate of donor-picked organs, which will be tested through the randomized clinical trial. However, no study so far has directly tested the effect of drugs with anti-inflammatory and anti-apoptotic properties administered to the donor in encephalic death in reducing inflammation of organs to be transplanted. This study aims to evaluate the use of liraglutide in patients with brain death in relation to their ability to attenuate the inflammation induced by encephalic death by means of a randomized clinical trial.


Clinical Trial Description

The intervention group will be composed of individuals deceased in brain dead, after the conclusion of the brain dead protocol by the teams responsible for the Intensive care and will receive liraglutide. The control group will be composed of the same population of individuals who died in brain dead of the intervention group, but will receive a placebo. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03672812
Study type Interventional
Source Hospital de Clinicas de Porto Alegre
Contact
Status Completed
Phase Phase 3
Start date September 1, 2018
Completion date February 10, 2022

See also
  Status Clinical Trial Phase
Recruiting NCT03765814 - The Anticipated Organ Donation Approach
Completed NCT02581111 - Naloxone for Optimizing Hypoxemia Of Lung Donors Phase 2/Phase 3
Completed NCT00808691 - Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit N/A
Completed NCT00998972 - N-acetyl-cysteine (NAC) and Kidney Graft Function Phase 3
Completed NCT04528797 - Thyroid and Adrenocortical Hormone Replacement in Organ Donors N/A
Completed NCT04303624 - Understanding Family Refusal
Completed NCT03098706 - Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function N/A
Not yet recruiting NCT04623294 - Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared Spectroscopy
Recruiting NCT02102945 - Special Imaging Technique to Aid in the Diagnosis of Patients in Coma After Cardiac Arrest N/A
Completed NCT02483273 - Alterations of Conjunctival Microcirculation in Brain Dead Patients N/A
Terminated NCT00675272 - Organ Donation and Hydrocortisone Treatment N/A
Completed NCT03262896 - Neurophysiological Examination in Patients With Brain Death
Recruiting NCT05202886 - "LiverColor": Machine Learning in Liver Photographs N/A
Completed NCT03281993 - Apnea Tests as the Methods of Brain Death Diagnosis. N/A
Completed NCT03179020 - Donation Network to Optimize Organ Recovery Study N/A
Completed NCT05070182 - Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)
Terminated NCT03439995 - Goal of Open Lung Ventilation in Donors N/A
Completed NCT02525510 - Deceased Organ Donor Interventions to Protect Kidney Graft Function N/A
Completed NCT02742857 - Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury Phase 1
Completed NCT02503813 - Does Venous pCO2 Increase by 20 mmHg or More During Apnea Challenge Test? N/A