Clinical Trials Logo
  1. Home
  2. Brain Death
  3. NCT00615225

Brain Death: Inflammatory Response, Apoptosis, and Endotoxin Tolerance

Brain Death Clinical Trial

Official title:
Observational Study on the Systemic Inflammatory Response During Brain Death.

Clinical Trial Summary

We hypothesized that brain death is associated with an early systemic inflammatory response, possibly combined with activation of apoptotic cell death, two events that may contribute to induce rapid organ dysfunction. In this study of brain-dead donors and controls, we assayed plasma cytokines and soluble factors, investigated plasma endotoxin levels as a triggering factor for inflammation, measured ex vivo cytokine production by blood leukocytes to determine whether immunosuppression occurred after brain death, and examined skeletal muscle biopsies to look for evidence of inflammation and increased apoptosis in peripheral tissue.

Clinical Trial Description

n/a

Study Design

N/A

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00615225
Study type Observational
Source Delafontaine Hospital
Contact
Status Completed
Phase N/A
Start date January 2000
Completion date December 2007
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT03765814 - The Anticipated Organ Donation Approach
Completed NCT02581111 - Naloxone for Optimizing Hypoxemia Of Lung Donors Phase 2/Phase 3
Completed NCT00808691 - Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit N/A
Completed NCT00998972 - N-acetyl-cysteine (NAC) and Kidney Graft Function Phase 3
Completed NCT04528797 - Thyroid and Adrenocortical Hormone Replacement in Organ Donors N/A
Completed NCT03672812 - The Use of Liraglutide in Brain Death Phase 3
Completed NCT04303624 - Understanding Family Refusal
Completed NCT03098706 - Therapeutic Hypothermia in "Expanded Criteria" Brain-dead Donors and Kidney-graft Function N/A
Not yet recruiting NCT04623294 - Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared Spectroscopy
Recruiting NCT02102945 - Special Imaging Technique to Aid in the Diagnosis of Patients in Coma After Cardiac Arrest N/A
Completed NCT02483273 - Alterations of Conjunctival Microcirculation in Brain Dead Patients N/A
Terminated NCT00675272 - Organ Donation and Hydrocortisone Treatment N/A
Completed NCT03262896 - Neurophysiological Examination in Patients With Brain Death
Not yet recruiting NCT06359119 - Implementation of Apnoea Test for Patients With Suspected Brain Death
Recruiting NCT05202886 - "LiverColor": Machine Learning in Liver Photographs N/A
Completed NCT03281993 - Apnea Tests as the Methods of Brain Death Diagnosis. N/A
Completed NCT03179020 - Donation Network to Optimize Organ Recovery Study N/A
Completed NCT05070182 - Resting Energy Needs in Brain Dead Patients (reSting EneRgy nEeds iN brAin DEad Patients)
Terminated NCT03439995 - Goal of Open Lung Ventilation in Donors N/A
Completed NCT02525510 - Deceased Organ Donor Interventions to Protect Kidney Graft Function N/A