Aneurysm Wall Histology Registry

Brain Aneurysm Clinical Trial

Official title: Aneurysm Wall Histology and Correlation With Cerebrospinal Fluid and Blood Plasma Registry

Status Completed

Clinical Trial Summary

The purpose of this prospective registry is to determine if patients harboring intracranial aneurysms have any predictive markers between aneurysm wall tissue, cerebrospinal fluid and blood plasma.

Clinical Trial Description

To design a registry to evaluate the wall of intracranial aneurysms during open surgical clipping by direct photographic appearance, wall biopsy samples, CSF and blood plasma fluid collection (Interleukins; IL-8/ Matrix Metalloproteinase; MMP-9) for complete evaluation and comparison.

The focus of the registry will be to determine the presence of aneurysmal wall defects, mural clot, atherosclerotic and atheroma, wall permeability and delamination. These findings will then be correlated to the collected CSF and blood values to determine if there is any direct features of the aneurysm wall that would predict any of the reported post embolic syndromes. The collected data can also be correlated to the peroperative imaging, (MRI, CT and Angiogram). ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Aneurysm
• Brain Aneurysm

• NCT number: NCT01444664
• Study type: Interventional
• Source: Medical University of South Carolina
• Status: Completed
• Phase: Phase 4
• Start date: June 2010
• Completion date: June 2015